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Stem Cell Pathology Viral Oncology Stem Cell Biology Public Health and International Health Forensic Science Molecular Immunology Laboratory Animal Medicine Cell Signaling Hematology, Respiratory Medicine, Rheumatology and Infectious Disease Medicine Otolaryngology, Head and Neck Surgery Stem Cell Disorders


Stem Cell Pathology

* Original Articles *

  1. Tanaka, K., Kumano, K. and Ueno, H. Intracellular signals of lung cancer cells as possible therapeutic targets. Cancer Sci. 106, 489-496, 2015.
  2. Komai, Y., Tanaka, T., Tokuyama, Y., Yanai, H., Ohe, S., Omachi, T., Atsumi, N., Yoshida, N., Kumano, K., Hisha, H., Matsuda, T. and Ueno H. Bmi1 expression in long-term germ stem cells. Sci. Rep. 4, Article No.6175, 2014.
  3. Hisha, H., Tanaka, T., Kanno, S., Tokuyama, Y., Komai, Y., Ohe, S., Yanai, H., Omachi, T. and Ueno, H. Establishment of a Novel Lingual Organoid Culture System: Generation of Organoids Having Mature Keratinized Epithelium from Adult Epithelial Stem Cells. Sci. Rep. 3, Article no.3224, 2013.
  4. Tanaka, T., Komai, Y., Tokuyama, Y., Yanai, H., Ohe, S., Okazaki, K. and Ueno, H. Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells. Nat. Cell Biol. 15, 511-518, 2013.
  5. Yanai, H., Tanaka, T. and Ueno, H. Multicolor lineage tracing methods and intestinal tumors. J. Gastroenterol. 48, 423-433, 2013.
  6. Zhang, H., Zheng, W., Shen, Y., Adhikari, D., Ueno, H. and Liu, K. Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries. Proc. Natl. Acad. Sci. U.S.A. 109, 12580-12585, 2012.
  7. Rinkevich, Y., Lindau, P., Ueno, H., Longaker, M. and Weissman, IL. Germ layer and lineage restricted stem/progenitors regenerate the mouse digit tip. Nature, 476, 409-413, 2011.



Viral Oncology

* Original Articles *

  1. Miwa, M., Ida, C., Yamashita, S., Tanaka, M. and Fujisawa, J. Poly(ADP-ribose). Structure, Physicochemical Properties and Quantification in vivo, with special reference to poly(ADP-ribose) binding protein modules. Curr. Protein Pept. Sci. 17, 683-692, 2016.
  2. Tezuka, K., Xun, R., Tei, M., Ueno, T., Tanaka, M., Takenouchi, N. and Fujisawa, JI. An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity. Blood, 123, 346-355, 2014.
  3. Ikebe, E., Kawaguchi, A., Tezuka, K., Taguchi, S., Hirose, S., Matsumoto, T., Mitsui, T., Senba, K., Nishizono, A., Hori, M., Hasegawa, H.,Yamada, Y., Ueno, T., Tanaka, Y., Sawa, H., Hall, A., Minami, Y., Jeang, K-T., Ogata, M., Morishita, K., Hasegawa,H., Fujisawa, JI. and Iha, H. Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration to multiple organs and improves survival period for ATL model mice. Blood Cancer J. 3, Article No.e132, 2013.
  4. Tezuka, K., Tei, M., Ueno, T., Xun, R. and Fujisawa, JI. Carrier model of HTLV-1 infection in humanized NOG mice. Retrovirology, 11, P43, 2014.
  5. Tezuka, K., Tei, M., Ueno, T., Xun, R., Iha, H. and Fujisawa, JI. Inhibition of ATL development in humanized mouse model by AZT/INF treatment. Retrovirology, 11, P43, 2014.
  6. Ikebe, E., Kawaguchi, A., Tezuka, K., Taguchi, S., Hirose, S., Matsumoto, T., Mitsui, T., Senba, K., Nishizono, A., Hori, M., Hasegawa, H., Yamada, Y., Ueno, T., Tanaka, Y., Sawa, H., Hall, W., Minami, Y., Jeang, K-T., Ogata, M., Morishita, K., Hasegawa, H., Fujisawa, JI. and Iha, H. A novel HSP90 inhibitor, 17-DMAG, induces Tax down-regulation and its oral administration to ATL-model mice intervenes against the infiltration property of the ATL-like lymphocytes and provides extended survival period. Retrovirology, 11 44, 2014.
  7. Nakamura, M., Kaneko, S., Ito, H., Jiang, S., Fujita, K., Wate, R., Nakano, S., Fujisawa, JI. and Kusaka, H. Activation of Transforming Growth Factor-β/Smad Signaling Reduces Aggregate Formation of Mislocalized TAR DNA-Binding Protein-43. Neurodegener Dis. 11, 182-193, 2012.
  8. Tanaka, M., Nitta, T., Sun, B., Fujisawa, J., Miwa, M. The route of primary HTLV-1 infection regulates HTLV-1 distribution in reservoir organs of infected mice. Exp. Thr. Med. 2, 89-94, 2011.

* Conference Articles *

  1. Joseph, A., Ueno, T., Ren, Y., Yao, J., Lee, S., Tanaka, M. and Fujisawa, J. Both HBZ Protein and mRNA are Required for Leukemic Growth of HTLV-l-infected T-cells in Humanized Mouse Model, 18th International Conference on Human Retrovirology, Tokyo, March, 2017
  2. Tanaka, M. Ren, Y., Yao, J., Lee, S., Takenouchi, N. and Fujisawa, J. Effect of Adjuvant in the Tax Vaccination of Humanized Mouse to Prevent HTLV-l Infection, 18th International Conference on Human Retrovirology, Tokyo, March, 2017
  3. Ikebe, E., Kawaguchi, A., Tezuka, K., Taguchi, S., Hirose, S., Matsumoto, T., Mitsui, T., Senba, K., Nishizono, A., Hori, M., Hasegawa, H., Yamada, Y., Ueno, T., Tanaka, Y., Sawa, H., Hall, W. Minami, Y., Jeang, KT., Ogata, M., Morishita, K., Hasegawa, H., Fujisawa, JI. and Iha, H. A novel HSP90 inhibitor, 17-DMAG, induces Tax down-regulation and its oral administration to ATL-model mice intervenes against the infiltration property of the ATL-like lymphocytes and provides extended survival period. 16th International Conference on Human Retroviruses: HTLV and Related Viruses, Montreal, CANADA, June, 2013.
  4. Ueno, T., Xun, R., Saito, M., Tezuka, K., Tanaka Y. and Fujisawa, JI. Altered pattern in viral mRNA expression of Iranian type HTLV-1 leading to enhanced viral expression. 16th International Conference on Human Retroviruses: HTLV and Related Viruses, Montreal CANADA, June, 2013.
  5. Tezuka, K., Tei, M., Ueno, T., Xun, R., Iha, H. and Fujisawa, JI. Inhibition of ATL development in humanized mouse model by AZT/INF treatment. 16th International Conference on Human Retroviruses: HTLV and Related Viruses, Montreal CANADA, June, 2013.
  6. Tezuka, K., Tei, M., Ueno, T., Xun, R. and Fujisawa, JI. Carrier model of HTLV-1 infection in humanized NOG mice. 16th International Conference on Human Retroviruses: HTLV and Related Viruses, Montreal CANADA, June, 2013.
  7. Ueno, T., Tezuka, K., Xun, R., Tei, M, Tanaka, M., Takenouchi, N., Fujisawa, JI. Infection of defective virus correlated with the induction of CD25 positive CD4 T-cell during early phase of infection in humanized mouse model. The XV International Congress of Virology, Sapporo, Sep. 2011.
  8. Tezuka, K., Xun, R., Tei, Ueno, T., Tanaka, M., Takenouchi, N., Fujisawa, JI. Inverse correlation between tax and CD25 expressions in HTLV-1 infected CD4+ T-cells in vivo. The XV International Congress of Virology, Sapporo, Sep. 2011.
  9. Tanaka, M., Wada, N., Hashimoto, I., Hasegawa, S., Tsuda, H., Miwa, M., Fujisawa, JI. Anti-tumor effects of bovine lactoferrin to lymphoma cells expressing HTLV-1 Tax. 70th Annual Meeting of the Japanese Cancer Association, Nagoya, Oct. 2011.



Stem Cell Biology

* Original Articles *

  1. Nakatsuka, R., Iwaki, R., Matsuoka, Y., Sumide, K., Kawamura, H., Fujioka, T., Sasaki, Y., Uemura, Y., Asano, H., Kwon, A-H. and Sonoda, Y. Identification and characterization of Lin-CD45-Sca-1+ VSEL phenotypic cells residing in adult bone tissue. Stem Cells Dev. 25, 27-42, 2016.
  2. Matsuoka, Y., Nakatsuka, R., Sumide, K., Kawamura, H., Takahashi, M., Fujioka, T., Uemura, Y., Asano, H., Sasaki, Y., Inoue, M., Ogawa, H., Takahashi, T., Hino, M. and Sonoda, Y. Prospectively Isolated Human Bone marrow Cell-Derived MSCs Support Primitive Human CD34-Negative Hematopoietic Stem Cells. Stem Cells, 33, 1554-1565, 2015.
  3. Nakatsuka, R., Matsuoka, Y., Uemura, Y., Sumide, K., Iwaki, R., Takahashi, M., Fujioka, T., Sasaki, Y. and Sonoda, Y. Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro. Cell Transplant, 24, 97-113, 2015.
  4. Matsuoka, Y., Sasaki, Y., Nakatsuka, R., Takahashi, M., Iwaki, R., Uemura, Y. and Sonoda, Y. Low level of c-kit expression marks deeply quiescent murine hematopoietic stem cells. Stem Cells 29, 1783-1791, 2011.
  5. Kimura, T., Kohno, H., Matsuoka, Y., Nakatsuka, R., Sasaki, Y., Fukuhara, S. and Sonoda, Y. CD16 antigen is a positive marker of peripheral blood-derived early endothelial progenitor cells. Int. J. Hematol. 93, 123-125, 2011
  6. Ishii, M., Matsuoka, Y., Sasaki, Y., Nakatsuka, R., Takahashi, M., Nakamoto, T., Yasuda, K., Matsui K, Asano, H., Uemura, Y., Tsuji, T., Fukuhara and Sonoda, Y. Development of a high-resolution purification method for precise functional characterization of primitive human cord blood-derived CD34-negative SCID-repopulating cells. Exp. Hematol. 39, 203-213, 2011.
  7. Kimura, T., Kohno, H., Matsuoka, Y., Murakami, M., Nakatsuka, R., Hase, M., Yasuda, K., Uemura, Y., Sasaki, Y., Fukuhara, S. and Sonoda Y. CXCL8 enhances the angiogenic activity of umbilical cord blood-derived outgrowth endothelial cells in vitro. Cell Biol. Int. 35, 201-208, 2011.

* Books *

  1. Sonoda, Y. Human CD34-negative hematopoietic stem cells. Adult Stem Cell Therapies : Alternatives to Plasticity. 53-77, Humana Press, Springer, Berlin, 2014.

* Conference Articles *

  1. Matsuoka, Y., Sumide, K., Kawamura, H., Nakatsuka, R., Fujioka, T., Sasaki, Y. and Sonoda, Y. Human bone marrow-derived CD271+SSEA-4+ mesenchymal stromal cells support hematopoietic stem/progenitor cells through the cell-cell contact. The 14th Stem Cell Research Symposium, Kobe, May, 2016
  2. Nakatsuka, R., Iwaki, R., Matsuoka, Y., Sumide, K., Fujioka, T., Sasaki, Y. and Sonoda, Y. Evaluation of Stem Cell Characteristics of Murine Bone-derived Small Cells. The 12th Stem Cell Research Symposium, Fukuoka, May, 2014
  3. Iwaki, R., Nakatsuka, R., Matsuoka, Y., Takahashi, M., Fujioka, T., Sasaki, Y. and Sonoda Y. Development of a highly efficient method for isolating bone-derived small stem cells identified in adult mouse bone. The 11th Stem Cell Research Symposium, Tokyo, May, 2013



Public Health and International Health

* Original Articles *

  1. Lamaningao, P., Kanda, S., Laimanivong, S., Shimono, T., Darcy, A.W. Phyaluanglath, A., Mishima, N. and Nishiyama, T. Development of a PCR assay for diagnosing trematode (opisthorchis and haplorchis) infections in human stools. Am. J. Trop. Med. Hyg. 96, 221–228, 2017.
  2. Phommanivong, V., Kanda, S., Shimono, T., Lamaningao, P., Darcy, A.W., Mishima, N., Phaytanavanh, B. and Nishiyama, T. Co-circulation of the dengue with chikungunya virus during the 2013 outbreak in the southern part of Lao PDR. Trop. Med. Health 44, 24, 2016.
  3. Hosomi, R., Fukunaga, K., Arai, H., Kanda, S., Nishiyama, T. and Yoshida, M. Effect of porcine hemoglobin on serum lipid content and fecal lipid excretion inrats. J. med. food, 17, 302-309, 2014.
  4. Hosomi, R., Fukunaga, K., Arai, H., Kanda, S., Nishiyama, T. and Yoshida, M. Effect of combination of dietary fish protein and fish oil on lipid metabolism in rats. J. food sci. technol. 50, 266-274, 2013.
  5. Yoshida, M., Hosomi, R., Fukunaga, K., Kanda, S. and Nishiyama, T. Tissue lanthanum deposition and phosphorus balance in rats with long-term dietary administration of lanthanum carbonate. Biomed. Res. Trace Elements, 23, 40-44, 2012.
  6. Tamada, Y., Kanda, S., Yoshidome, A., Hayashi, I., Miyake, M. and Nishiyama, T. Diagnosis of active tuberculosis using MPB64, a specific antigen of Mycobacterium bovis. Microbiol. Immunol. 56, 740-747, 2012.
  7. Ooka, H., Kanda, S., Okazaki, H., Suzuki, H., Mishima, K., Saito, I., Yagi, M., Tomoda, K. and Nishiyama, T. Characterization of side population (SP) cells in murine cochlear nucleus. Acta Otolaryngol. 132, 693-701, 2012.
  8. Osumi, Y., Shibata, S. B., Kanda, S., Yagi, M., Ooka, H., Shimano, T., Mikiya A., Kawamoto, K., Kuriyama, H., Inoue, T., Nishiyama, T., Yamashita, T., Tomoda, K. Downregulation of N-methyl-D-aspartate receptor ζ1 subunit (GluN1) gene in inferior colliculus with aging. Brain Res. 1454, 23-32, 2012.

* Conference Articles *

  1. Phommanivong, V., Kanda, S., Shimono, T., Lamaningao, P., Darcy, A.W. and Mishima, N. Bounthanh Phaytanavanh, and Toshimasa Nishiyama. Co-circulation of the dengue with chikungunya virus during the 2013 outbreak in the southern part of Lao PDR. 10th National Health Research Forum. Savannakhet, LAO P.D.R. Oct. 2016
  2. Fukunaga, K., Hosomi, R., Arai, H., Kanda, S., Nishiyama, T. and Yoshida, M. Dietary Hemoglobin Reduce Serum and Liver Cholesterol Contents and Increase Fecal Fatty Acids, Cholesterol, and Bile Acids in Rats. 104th American Oil Chemists' Society Annual Meeting & Expo, Montreal, CANADA, April, 2013.
  3. Mishima, N., Yoshikawa, M., Shimono, T., Nakatani, I., Ishizaki, H., Miyake, M., Kanda, S. and Nishiyama, T. A Comparative Study on Efficacy of Purified Chick Embryo Cell Rabies Vaccine (Rabipur®) as a Pre-exposure Prophylaxis for the Japanese, Administering three doses on days 0, 7, 21 or 28 and three doses on days 0, 30, 180. The 13th Conference of the International Society of Travel Medicine, Maastricht, Netherlands, May, 2013.
  4. Kanda, S., Ooka, H., Okazaki, H., Suzuki, H., Nishiyama, T. Preparation and characterization of pituitary stem progenitor cells in mouse. 9th Annual Meeting, International Society for Stem Cell Research, Tront CANADA, June, 2011.
  5. Ooka, H., Kanda, S., Nishiyama, T., Tomoda, K., Okazaki, H. Identification of tissue specific Stem/Progenitor Cells in Auditory Pathway. 9th Annual Meeting, International Society for Stem Cell Research, Tront CANADA, June, 2011.



Forensic Science

* Original Articles *

  1. Hashiyada, M., Akane, A., Matsumoto, T., Yoshimura, S. and Tokiyasu, T. Constructing the SNP database of Japanese population using the HID-Ion AmpliSeqTM Ancestry Panel on the Ion PGMTM System. Human Identification Solutions Conference, Barcelona, Spain. May, 2016



Molecular Immunology

* Original Articles *

  1. Kondo, N., Ueda, Y., Kita, T., Ozawa, M., Tomiyama, T., Yasuda, K., Lim, D.S. and Kinashi, T. NDR1-dependent regulation of kindlin-3 controls high-affinity LFA-1 binding and immune synapse organization. Mol Cell Biol. 37, e00424-16, 2017.
  2. Ueda, Y., Kondo, N., Ozawa, M., Yasuda, K., Tomiyama, T. and Kinashi, T. Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition. J. Immunol. 196, 3019-3031, 2016.
  3. Iida, T., Saito, K., Katagiri, K., Kinashi, T. and Ohta, Y. The RacGAP protein FilGAP is a negative regulator of chemokine-promoted lymphocyte migration. FEBS Lett. 590, 1395-1408, 2016.
  4. Katakai, T. and Kinashi, T. Microenvironmental control of high-speed interstitial T cell migration in the lymph node. Front Immunol. 7, 194, 2016.
  5. Ishibashi, M., Miyanaga, Y., Matsuoka, S., Kozuka, J., Togashi, Y., Kinashi, T. and Ueda, M. Integrin LFA-1 regulates cell adhesion via transient clutch formation. Biochem. Biophys. Res. Commun. 464, 459-66. 2015.
  6. Katakai, T., Kondo, N., Ueda, Y. and Kinashi, T. Autotaxin Produced by Stromal Cells Promotes LFA-1-Independent and Rho-Dependent Interstitial T Cell Motility in the Lymph Node Paracortex. J. Immunol. 193, 617-626, 2014.
  7. Nishikimi, A., Ishihara, S., Ozawa, M., Etoh, K., Fukuda, M., Kinashi, T. and Katagiri, K. Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking. Sci. Signal. 7, ra72 2014.
  8. Katakai, T., Kondo, N., Ueda, Y. and Kinashi, T. Autotaxin Produced by Stromal Cells Promotes LFA-1-Independent and Rho-Dependent Interstitial T Cell Motility in the Lymph Node Paracortex. J. Immunol. 193, 617-626, 2014.
  9. Nakamura, T., Yasuda, S., Nagai, H., Koinuma, S., Morishita, S., Goto, A., Kinashi, T. and Wada, N. Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase. Genes Cells. 18, 1020-1031. 2013.
  10. Yamamoto-Taguchi, N., Satou, Y., Miyazato, P., Ohshima, K., Nakagawa, M., Katagiri, K., Kinashi, T., Matsuoka, M. HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression. PLoS Pathog. 9, e1003630, 2013.
  11. Tomiyama, T., Ueda, Y., Katakai, T., Kondo, N., Okazaki, K. and Kinashi, T. Antigen-specific suppression and immunological synapse formation by regulatory T cells require the mst1 kinase. PLoS One, 8, e73874, 2013.
  12. Katakai, T., Habiro, K. and Kinashi, T. Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1/ICAM-1. J. Immunol. 191, 1188-1199, 2013.
  13. Chung, C., Kim, T., Kim, M., Kim, M., Song, H., Kim, TS., Seo, E., Lee, SH., Kim, H., Kim, SK., Yoo, G., Lee, DH., Hwang, DS., Kinashi, T., Kim, JM. and Lim, DS. Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis. Proc. Natl. Acad. Sci. USA. 110, 7732-7737, 2013.
  14. Ueda, Y., Katagiri, K., Tomiyama, T., Yasuda, K., Habiro, K., Katakai, T., Ikehara, S., Matsumoto, M. and Kinashi, T. Mst1 regulates integrin-dependent thymocyte trafficking and antigen-recognition in the thymus. Nat. Commun. 3, 1098, 2012.
  15. Sekine, K., Kawauchi, T., Kubo, K., Honda, T., Herz, J., Hattori, M., Kinashi, T. and Nakajima, K. Reelin controls neuronal migration and positioning by promoting neuronal adhesion to extracellular matrix via the inside-out activation of integrin α5β1. Neuron 76, 353-369, 2012.
  16. Fujii, Y., Shiota, M., Ohkawa, Y., Baba, A., Wanibuchi, H., Kinashi, T., Kurosaki, T. and Baba, Y. Surf4 modulates STIM1-dependent calcium entry. Biochem. Biophys. Res. Commun. 422, 615-620, 2012.
  17. Harada, Y., Tanaka, Y., Terasawa, M., Pieczyk, M., Habiro, K., Katakai, T., Hanawa-Suetsugu, K., Kukimoto-Niino, M., Nishizaki, T., Shirouzu, M., Duan, X., Uruno, T., Nishikimi, A., Sanematsu, F., Yokoyama, S., Stein, J.V., Kinashi, T. and Fukui, Y. DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood. 119, 4451-4461, 2012.
  18. Hnanawa-Suetsugu, K., Kukimoto-Niino, M., Mishima-Tsumagari, C., Akasaka, R., Ohsawa, N., Sekine, S., Ito, T., Tochio, N., Koshiba, S., Kigawa, T., Terada, T., Shirouzu, M., Nishikimi, A., Uruno, T., Katakai, T., Kinashi, T., Kohda, D., Tukui, Y. and Yokoyama, S. Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms. Proc. Natl. Acad. Sci. USA. 109, 3305-3310, 2012.
  19. Kinashi, T. Overview of integrin signaling in the immune system. Methods Mol. Biol. 757, 261-278, 2012.

* Conference Articles *

  1. Ueda, Y., Kondo, N. and Kinashi, T. Rap1-deficiency caused defective lymph node homing of lymphocytes and thymocyte-selection.( 3-E-W31-11-O/P) The 45th Annual Meeting of the Japanese Society for Immunology, Okinawa, Dec. 2016
  2. Kondo, N., Ueda, Y. and Kinashi, T. High-affinity LFA-1/ICAM-1 binding triggers the reorganization of vesicular transport regulators to facilitate the maturation of immunological synapse. The 39th Annual Meeting of the Molecular Biology Society of Japan, Yokohama, Nov.-Dec. 2016
  3. Ueda, Y., Kondo, N.,Ozawa, M. and Kinashi, T. Visualization of Rap1 activation during thymocyte development within the thymic tissues by 2-photon microscopy. International Symposium on Multi-dimensional Fluorescence Live Imaging of Cellular Functions and Molecular Activities, Kyoto, Jan. 2015.
  4. Kinashi, T., Ueda, Y., Kondo, N. Visualization of thymocyte trafficking and selection processes: the importance of Rap1 signaling and integrins. International Symposium on Multi-dimensional Fluorescence Live Imaging of Cellular Functions and Molecular Activities, Kyoto, Jan. 2015.
  5. Kondo, N., Ueda, Y., Kataka, T. and Kinashi, T. Administration of LFA-1 conformational changes at immune cell contact sites. The 4th Annual Meeting for Whole-Organism Science Society, Toyonaka, Osaka, Sep. 2014.
  6. Kondo, N., Ueda, Y., Kataka, T. and Kinashi, T. Single molecule measurement of ICAM-1/LFA-1 and the role of effector molecules on ICAM-1/LFA-1 regulation using total internal reflection microscopy. The 37th NAITO CONFERENCE ON Bioimaging-a paradigm shift for the life sciences, Niseko, Hokkaido, July, 2014.
  7. Ueda, Y. and Kondo, N., and Kinashi, T. Sema3E-Plexin signals regulate thymocyte migration by modulating Rap-1-dependent integrin activation, The 37th NAITO CONFERENCE ON Bioimaging-a paradigm shift for the life sciences, Niseko, Hokkaido, July, 2014.
  8. Kinashi, T., and Kondo, N. Single-Molecule Analysis of LFA-1/ICAM-1 Binding in Lymphocyte. Biophysical Society 58th Annual Meeting, the Moscone Center, San Francisco, USA. Feb. 2014.
  9. Kinashi, T. Regulation of immune cell trafficking and antigen recognition through Rap1 signaling. The 21st Hot Spring Harbor Symposium jointly with 9th Global COE International Symposium: Cell Migration in Biology and Medicine, Fukuoka, Jan. 2012.
  10. Kinashi, T. Regulation of thymocyte trafficking and antigen recognition within thymic tissues through integrins and Rap1 effector Mst1. Keystone Symposia on Molecular and Cellular Biology Chemokines and Leukocyte Trafficking in Homeostasis and Inflammatio, Breckenridge USA, Jan. 2012.
  11. Katakai, T., Kinashi, T. High-speed interstitial T cell migration within lymph node parenchyma involves LFA-1-dependent and -independent motility modes. 2011 The Annual Meeting of the Japanese Society for Immunology, Chiba, Nov. 2011.
  12. Ueda, Y., Katagiri, K., Tomiyama, T., Yasuda, K., Habiro, K., Katakai, T., Ikehara, S., Kinashi, T. Mst1 regulates thymocyte trafficking and antigen recognition within thymic tissues. 2011 The Annual Meeting of the Japanese Society for Immunology, Chiba, Nov. 2011.
  13. Habiro, K., Katakai, T., Kinashi, T. Two-step model of T cell-DC primary contacts and roles of integrin-regulatory Mst1.2011 The Annual Meeting of the Japanese Society for Immunology, Chiba Japan, Nov. 2011.
  14. Kinashi, T., Katagiri, K., Katakai T., Ueda, Y., Habiro, K. Crucial roles of Mst1 and RAPL (RASSF5) in lymphocyte adhesion and proliferation. 2nd International RASSF Symposium, Oxford UK, July 2011.
  15. Kinashi, T., Katagiri, K., Katakai T., Ueda, Y., Habiro, K. Cell migration and antigen recognition within lymph nodes and thymus. London Research Institute Cancer Research UK, London UK, July 2011.



Laboratory Animal Medicine

* Conference Articles *

  1. Tanaka, M., Yao, J., Lee, S.I., Ren, Y., Takenouchi, N. and Fujisawa, J. Induction of APOBEC3B cytidine deaminase gene in HTLV-1 infected T-cells of ATL model mouse. 17th HTLV conference. Martinique F.W.I., June, 2015
  2. Jun-ichi Fujisawa, Sung-il Lee, Jinchun Yao, Yihua Ren, Masakazu Tanaka. Tax peptide vaccine suppressed the leukemia in humanized mouse model of ATL. 17th HTLV conference. Martinique F.W.I., June, 2015



Cell Signaling

* Original Articles *

  1. Arima, M., Cui, D., Kimura, T., Sonoda, K.H., Ishibashi, T., Matsuda, S. and Ikeda, E. Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy. Sci. Rep. 6, 38445, 2016.
  2. Cui, D., Arima, M., Takubo, K., Kimura, T., Horiuchi, K., Minagawa, T., Matsuda, S., and Ikeda, E. ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function. Sci. Rep. 5, 12796, 2015.
  3. Hoshii, T., Kasada, A., Hatakeyama, T., Ohtani, M., Tadokoro, Y., Naka, K., Ikenoue, T., Ikawa, T., Kawamoto, H., Fehling, H.J., Araki, K., Yamamura, K., Matsuda, S., and Hirao, A. Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells. Proc. Natl. Acad. Sci. USA. 111, 3805-3810, 2014.
  4. Hoshii, T., Matsuda, S. and Hirao, A. Pleiotropic roles of mTOR complexes in haemato-lymphopoiesis and leukemogenesis. J. Biochem. 156, 73-83, 2014.
  5. Takayama, G., Ohtani, M., Minowa, A., Matsuda, S. and Koyasu, S. Class I PI3K-mediated Akt and ERK signals play a critical role in FceRI-induced degranulation in mast cells. Int.Immunol. 25, 215-220, 2013.
  6. Powers, S.E., Mandal, M., Matsuda, S., Miletic, A.V., Cato, M.C., Tanaka, A., Rickert, R.C., Koyasu, S. and Clark, MR. Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression. J. Exp. Med. 209, 2199-2213, 2012.
  7. Ohtani, M., Hoshii, T., Fujii, H., Koyasu, S., Hirao, A. and Matsuda, S. Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production. J. Immunol. 188, 4736-4740, 2012.
  8. Kurebayashi, Y., Nagai, S., Ikejiri, A., Ohtani, M., Ichiyama, K., Baba, Y., Yamada, T., Egami, S., Hoshii, T., Hirao, A., Matsuda, S. and Koyasu, S. PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi-1 expression and nuclear translocation of RORγ. Cell Rep. 1, 360-373, 2012.
  9. Yokoyama, T., Matsuda, S., Takae, Y., Wada, N., Nishikawa, T., Amagai, M., and Koyasu, S. Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris. Int. Immunol. 23, 365-373, 2011.

* Conference Articles *

  1. Yamana, A., Yamashita, A., Suzuki, M., Matsui, Y., Watanabe, T., and Matsuda, S. Forced expression of a constitutively active form of p110δ results in decrease of double positive thymocytes during thymocyte development. The 34th Annual Meeting of the Molecular Biology Society of Japan, Yokohama, Dec. 2011.
  2. Matsuda, S. and Ohatni, M. Role of the mTORC1 signaling pathway in T cell development. The 2012 Annual Meeting of the Japan Society for Immunology, Makuhari, Nov. 2011.
  3. Ohatni, M. and Matsuda, S. Role of mTORC1 in immune function of dendritic cells. The 2012 Annual Meeting of the Japan Society for Immunology, Makuhari, Nov. 2011.
  4. Nagai, S., Kurebayashi, Y., Baba, Y., Matsuda, S., and Koyasu, S. PI3K-Akt-mTORC1 axis controls Th17 differentiation by regulation of Gfi-1 and RORγt. The 2012 Annual Meeting of the Japan Society for Immunology, Makuhari, Nov. 2011.
  5. Fujii, H., Matsuda, S., Ohtani, M., and Koyasu, S. Role of class IA PI3K in regulatory T cell function. The 2012 Annual Meeting of the Japan Society for Immunology, Makuhari, Nov. 2011.



Hematology, Respiratory Medicine, Rheumatology and Infectious Disease Medicine

* Original Articles *

  1. Azuma, Y., Nakaya, A., Hotta, M., Fujita, S., Tsubokura, Y., Yoshimura, H., Satake, A., Ishii, K., Ito, T. and Nomura, S. Disseminated intravascular coagulation observed following treatment with gemtuzumab ozogamicin for relapsed/refractory acute promyelocytic leukemia. Mol. Clin. Oncol. 5, 31-34, 2016.
  2. Fujita, Y., Nakaya, A., Fujita, S., Hotta, M., Yoshimura, H., Azuma, Y., Nakanishi, T., Satake, A., Ishii, K., Ito, T. and Nomura, S. Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report. Mol. Clin. Oncol. 4, 151-153, 2016.
  3. Esaki, A., Ishii, K., Azuma, Y., Tsubokura, Y., Yoshimura, H., Hotta, M., Nakanishi, T., Fujita, S., Nakaya, A., Satake, A., Ito, T. and Nomura, S. Rapid improvement of hyperammonemic encephalopathy by bortezomib treatment in IgD-type multiple myeloma. Rinsho Ketsueki, 57, 854-858, 2016.
  4. Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y., Hotta, M., Yoshimura, H., Ishii, K., Ito, T. and Nomura, S. Enhanced international prognostic index in Japanese patients with diffuse large B-cell lymphoma. Leuk. Res. Rep. 6, 24-26, 2016.
  5. Nakaya, A., Fujita, S., Satake, A., Nakanishi, T., Azuma, Y., Tsubokura, Y., Hotta, M., Yoshimura, H., Ishii, K., Ito, T. and Nomura, S. Delayed HBV reactivation in rituximab-containing chemotherapy: How long should we continue anti-virus prophylaxis or monitoring HBV-DNA? Leuk. Res. 50, 46-49, 2016.
  6. Tsubokura, Y., Satake, A., Hotta, M., Yoshimura, H., Fujita, S., Azuma, Y., Nakanishi, T., Nakaya, A., Ito, T., Ishii, K. and Nomura, S. Successful treatment with mogamulizumab followed by allogeneic hematopoietic stem-cell transplantation in adult T-cell leukemia/lymphoma: a report of two cases. Int. J. Hematol. 104, 744-748, 2016.
  7. Nomura, S., Maeda, Y., Ishii, K., Katayama, Y., Yagi, H., Fujishima, N., Ota, S., Moriyama, M., Ikezoe, T., Miyazaki, Y., Hayashi, K., Fujita, S., Satake, A., Ito, T., Kyo, T. and Tanimoto, M. Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation. J. Blood Med. 7, 1-4, 2016.
  8. Shibata, T., Ohto, U., Nomura, S., Kibata, K., Motoi, Y., Zhang, Y., Murakami, Y., Fukui, R., Ishimoto, T., Sano, S., Ito, T., Shimizu, T. and Miyake, K. Guanosine and its modified derivatives are endogenous ligands for TLR7. Int. Immunol. 28, 211-222, 2016.
  9. Ito, T., Anti-inflammatory effects of statins -Novel investigation of the potent activity to human dendritic cell subsets as therapeutic cellular targets-. Cytometry Research 25, 19-24, 2015.
  10. Nakanishi, T. Inaba, M., Inagaki-Katashiba, N., Tanaka, A., Vien, P.T., Kibata, K., Ito, T. and Nomura S. Platelet-derived RANK ligand enhances CCL17 secretion from dendritic cells mediated by thymic stromal lymphopoietin. Platelets. 27, 1-7, 2014.
  11. Murakami-Satsutani, N., Ito, T., Nakanishi, T. Inagaki, N., Tanaka, A., Vien, P.T., Kibata, K., Inaba, M. and Nomura, S. IL-33 Promotes the Induction and Maintenance of Th2 Immune Responses by Enhancing the Function of OX40 Ligand. Allergol. Int. 63, 443-455, 2014.
  12. Ito, T., Ozaki, Y., Son, Y., Nishizawa, T., Amuro, H., Tanaka, A., Tamaki, T. and Nomura,S. Combined use of ursodeoxycholic acid and bosentan prevents liver toxicity caused by endothelin receptor antagonist bosentan monotherapy: two case reports. J. Med. Case Rep. 8, 250, 2014.
  13. Nomura, S., Ishii, K., Fujita, Y., Azuma, Y., Hotta, M., Yoshimura, Y., Nakanishi, T., Fujita, S., Nishizawa, T., Nakaya, A., Tamaki, T., Satake, A. and Ito, T. Immunotherapeutic effects of Ninjin-youei-to on patients with multiple myeloma. Curr. Trends Immunol. 15, 19-27, 2014.
  14. Ueba, T., Nomura, S., Inami, N., Yokoi, T. and Inoue, T. Elevated RANTES level is associated with metabolic syndrome and correlated with activated platelets associated markers in healthy younger men. Clin. Appl. thromb.hemostasis. 20, 813-818, 2014.
  15. Ogata, M., Ito, T., Shimamoto, K., Nakanishi, T., Satsutani, N., Miyamoto, R. and Nomura, S. Plasmacytoid dendritic cells have a cytokine-producing capacity to enhance ICOS ligand-mediated IL-10 production during T-cell priming. Int. Immunol. 25, 171-182, 2012.
  16. Fujita, S., Nakanishi, T., Yoshimura, H., Hotta, M., Nakamichi, N., Tamaki, T., Ishii, K., Ito, T. and Nomura, S. TGFβ(1) and sCTLA-4 levels are increased in eltrombopag-exposed patients with ITP. Thromb. Res. 130, 415-419, 2012.
  17. Nomura, S., Taniura, T., Shouzu, A., Omoto, S., Inami, N., Fujita, S., Tamaki, T., Yokoi, T., Shimizu, T. and Ito, T. Effects of pitavastatin on plasminogen activator inhibitor-1 in hyperlipidemic patients. Int. J. Gen. Med. 5, 535-540, 2012.
  18. Ito, T. and Arima, K. Cellular and molecular mechanisms of TSLP function in human allergic disorders--TSLP programs the“Th2 code”in dendritic cells--. Allergology International, 61, 35-43, 2012.
  19. Ito, T. Plasmacytoid dendritic cells and type I interferon as therapeutic cellular and molecular targets of autoimmune diseases. Cytometry Research, 22, 37-46, 2012.
  20. Nomura, S., Fujita, S., Nakanishi, T., Yokoi, T., Shimamoto, K., Miyamoto, R. and Ito, T. Platelet-derived microparticles cause CD154-dependent activation of dendritic cells. Platelets, 23, 81-82, 2011.
  21. Lande, R., Ganguly, D., Facchinetti, V., Frasca, L., Conrad, C., Gregorio, J., Meller, S., Chamilos, G., Sebasigari, R., Riccieri, V., Bassett, R., Amuro, H., Fukuhara, S., Ito, T., Liu, YJ. and Gilliet, M. Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus. Sci. Transl. Med. 3, 73ra19, 2011.
  22. Hoshino, S., Kurishima, A., Inaba, M., Ando, Y., Fukui, T., Uchida, K., Nishio, A., Iwai, H., Yokoi, T., Ito, T., Hasegawa-Ishii, S., Shimada, A., Li, M., Okazaki, K. and Ikehara, S. Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells. J. Gastroenterol. 46, 1368-1381, 2011.
  23. Katashiba, Y., Miyamoto, R., Hyo, A., Shimamoto, K., Murakami, N., Ogata, M., Amakawa, R., Inaba, M., Nomura, S., Fukuhara, S. and Ito, T. Interferon-α and interleukin-12 are induced, respectively, by double-stranded DNA and single-stranded RNA in human myeloid dendritic cells. Immunology, 132, 165-173, 2011.
  24. Nomura, S., Fujita, S., Ozasa, R., Nakanishi, T., Miyaji, M., Mori, S., Ito, T. and Ishii, K. The correlation between platelet activation markers and HMGB1 in patients with disseminated intravascular coagulation and hematologic malignancy. Platelets. 22, 396-397, 2011.
  25. Nomura, S., Ozasa, R., Nakanishi, T., Fujita, S., Miyaji, M., Mori, S., Yokoi, T., Ito, T. and Ishii, K. Can recombinant thrombomodulin play a preventive role for veno-occlusive disease after haematopoietic stem cell transplantation? Thromb. Haemost. 105, p1118-1120, 2011.
  26. Nomura, S., Nakanishi, T., Ozasa, R., Fujita, S., Miyaji, M., Mori, S., Yokoi, T., Ishii, K. and Tomoki, Ito. Dynamic role of cell-derived microparticles in hematopoietic stem cell transplantation. Curr. Trends Immunol. 12, 21-27, 2011.

* Conference Articles *

  1. Ito, T. Immunomodulatory Drugs (IMiDs), lenalidomide and pomalidomide, suppress Th1-inducing capacity of dendritic cells but enhance Th2-mediated allergic response. 58th ASH Annual Meeting2016 - The American Society of Hematology, San Diego, U.S.A. Dec. 2016
  2. Kibata, K. Lenalidomide, a derivative of thalidomide, acts as immunoenhancer of typeⅠinterferon production from plasmacytoid dendritic cells. 13th International symposium on Dendritic cells(DC2014), Tours, France, Sep. 2014
  3. Inagaki-Katashiba, N. Statins, HMG-CoAreductase inhibitors, have a potential to regulate DC-derived factors involved in TSLP-mediated allergic responses. 13th International symposium on Dendritic cells(DC2014), Tours, France, Sep. 2014
  4. Tanaka, A. Novel usage of recombinant thrombomodulin as an inhibitor of type I interferon production by plasmacytoid dendritic cells. 13th International symposium on Dendritic cells(DC2014), Tours, France, Sep. 2014
  5. Iwata, R. Therapeutical doses of temozolomide inhibit IL-10 production by dendritic cells and enhance the CTL response. 13th International symposium on Dendritic cells(DC2014), Tours, France, Sep. 2014
  6. Vien, P.T. Analogs of thalidomide act as immunomodulators of human myeloids dendritic cells. 13th International symposium on Dendritic cells(DC2014), Tours, France, Sep. 2014



Otolaryngology, Head and Neck Surgery

* Original Articles *

  1. Osumi, Y., Shibata, SB., Kanda, S., Yagi, M., Ooka, H., Shimano, T., Asako, M., Kawamoto, K., Kuriyama, H., Inoue, T., Nishiyama, T., Yamashita, T., Tomoda, K. Downregulation of N-methyl-D-aspartate receptor ζ1 subunit (GluN1) gene in inferior colliculus with aging. Brain Res. 1454, 23-32, 2012.
  2. Ooka, H., Kanda, S., Okazaki, H., Suzuki, H., Mishima, K., Saito, I., Yagi, M., Tomoda, K. and Nishiyama, T. Characterization of side population (SP) cells in murine cochlear nucleus. Acta Otolaryngol. 132, 693-701, 2012.
  3. Shimano, T., Fyk-Kolodziej, B., Mirza, N., Asako, M., Tomoda, K., Bledsoe, S., Pan, ZH., Molitor, S. and Holt, AG. Assessment of the AAV- mediated expression of channelrhodopsin-2 and halorhodopsin in brainstem neurons mediating auditory signaling. Brain Res. 12, 01676-9, 2012.



Stem Cell Disorders

* Original Articles *

  1. Shi, M., Li, M., Cui, Y., Adachi, Y. and Ikehara, S. Gr-1 Ab administered after bone marrow transplantation plus thymus transplantation suppresses tumor growth by depleting granulocytic myeloid-derived suppressor cells. PloS One 9, e97908, 2014.
  2. Ikehara S. Advances in leukemia treatment with bone marrow transplantation. J. Leuk. 2, 136, 2014.
  3. Li, M., and Ikehara, S. Bone marrow stem cell as a potential treatment for diabetes. J. Diabetes Res. 329596, 2013.
  4. Li, M., and Ikehara, S. Bone-marrow-derived mesenchymal stem cells for organ repair. Stem Cells Int. 132642, 2013
  5. Shi, M., Li, M., Cui, Y., Liu, L., Adachi, Y. and Ikehara S. CD4+ T cell-depleted lymphocyte infusion impairs neither the recovery of recipient thymus nor the development of transplanted thymus. J Immunol. 190, 2976-2983, 2013.
  6. Shimo, T., Adachi, Y., Yamanouchi, S., Tsuji, S., Kimata, T., Umezawa, K., Okigaki, M, Takaya, J., Ikehara, S. and Kaneko, K. A novel nuclear factor κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates puromycin aminonucleoside-induced nephrosis in mice. Am. J. Nephrol. 37, 302-309, 2013.
  7. Zhang, Y., Hosaka, N., Cui, Y., Shi, M., Li, M., Li, Q. and Ikehara S. Effects of intra-bone marrow-bone marrow transplantation plus adult thymus transplantation on survival of mice bearing leukemia. Stem Cells Dev. 21, 1441-1448, 2012.
  8. Shima, C., Adachi, Y., Minamino, K., Okigaki, M., Shi, M., Imai, Y., Yanai, S., Takahashi, K. and Ikehara, S. Neuroprotective effects of granulocyte colony-stimulating factor on ischemia-reperfusion injury of the retina. Ophthalmic Res.. 48, 199-207, 2012.
  9. Li, M., Vanella, L., Zhang, Y., Shi, M., Takaki, T., Shapiro, JI. and Ikehara, S. Stem cell transplantation increases antioxidant effects in diabetic mice. Int. J. Biol. Sci. 8, 1335-1344, 2012.
  10. Zhang, Y., Hosaka, N., Cui, Y., Shi, M. and Ikehara, S. Effects of allogeneic hematopoietic stem cell transplantation plus thymus transplantation on malignant tumors: Comparison between fetal, newborn, and adult mice. Stem Cells Dev. 20, 599-607, 2011.
  11. Oe, K., Kushida, T., Okamoto, N., Umeda, M., Nakamura, T., Ikehara, S. and Iida, H. New strategies for anterior cruciate ligament partial rupture using bone marrow transplantation in rats. Stem Cells Dev. 20, 671-679, 2011.
  12. Shi, M., Lian, Z., Zhang, Y., Yanai, S., Shima, C., Imai, Y. and Ikehara, S. Combination of intra-bone marrow-bone marrow transplantation and subcutaneous donor splenocyte injection diminishes risk of GVHD and enhances survival rate. Stem Cells Dev. 20, 759-768, 2011.
  13. Ikehara, S. Thymus transplantation for treatment of cancer: lessons from murine models. Expert Rev. Clin. Immunol. 7, 205-211, 2011.
  14. Mori, S., Fujita, S., Yamamoto, Y., Li, M., Fukuhara, S., Nomura, S. and Ikehara, S. Perfusion method for bone marrow cell collection in poor mobilizer lymphoma patient. Int. J. Hematol. 93, 822-824, 2011.
  15. Ikehara, S. A novel BMT technique for treatment of various currently intractable diseases. Best Pract. Res. Clin. Haematol. 24, 477-483, 2011.
  16. Hoshino, S., Kurishima, A., Inaba, M., Ando, Y., Fukui, T., Uchida, K., Nishio, A., Iwai, H., Yokoi, T., Ito, T., Ishii, S., Shimada, A., Li, M., Okazaki, K. and Ikehara, S. Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells. J. Gastroenterol. 46, 1368-1381, 2011.
  17. Zhang, Y., Hosaka, N., Cui, Y., Shi, M., Li, M., Li, Q. and Ikehara, S. Effects of intra-bone marrow-bone marrow transplantation plus adult thymus transplantation on survival of mice bearing leukemia. Stem Cells Dev. 21, 1441-1448, 2011.

* Conference Articles *

  1. Ikehara, S. Autoimmune diseases as stem cell disorders: Rationale for normal stem cell transplantation for their treatment. The 5th Autoimmunity Congress Asia (ACA 2011). Invited lecture, Singapore, Nov. 2011.


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