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Molecular Pharmacology, Matrix Biology and Medicine Cardiology, Nephrology, and Endocrinology and Metabolism Gastroenterology and Hepatology Surgery Dermatology Plastic and Reconstructive Surgery Ophthalmology and Visual Science Radiology Clinical Sciences and Laboratory Medicine Pathology and Laboratory Medicine Biophysics


Molecular Pharmacology, Matrix Biology and Medicine

* Original Articles *

  1. Fujikawa, Y., Yoshida, H., Inoue, T., Ohbayashi, T., Noda, K,. von Melchner, H., Iwasaka, T., Shiojima, I., Akama, TO. and Nakamura, T. Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development. Sci. Rep. 7, 43714, 2017.
  2. Kageshima, M., Maruyama, T., Akama, T. and Nakamura, T. Novel magnetic indenter for rheological analysis of thin biological sheet for regenerative medicine. Rev. Sci. Instrum. 87, 074302, 2016.
  3. Fanhchaksai, K., Okada, F., Nagai, N., Pothacharoen, P., Kongtawelert, P., Hatano, S., Makino, S., Nakamura, T., Watanabe, H. Host stromal versican is essential for cancer-associated fibroblast function to inhibit cancer growth. Int. J. Cancer 138, 630-641, 2016.
  4. Bultmann-Mellin, I., Conradi, A., Maul, A.C., Dinger, K., Wempe, F., Wohl, A.P., Imhof, T., Wunderlich, F.T., Bunck, A.C., Nakamura, T., Koli, K., Bloch, W., Ghanem, A., Heinz, A., von Melchner, H., Sengle, G., Sterner-Kock, A. Modeling autosomal recessive cutis laxa type 1C (ARCL1C) in mice reveals distinct functions of Ltbp-4 isoforms. Dis. Model Mech. 8, 403-15, 2015.
  5. Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Nakazeki, F., Ide, Y., Koyama, S., Sowa, N., Yahagi, N., Shimano, H., Nakamura, T., Hasegawa, K., Kume, N., Yokode, M., Kita, T., Kimura, T., Ono, K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci. Rep. 4, 5312, 2014.
  6. Yokoyama, U., Minamisawa, S., Shioda, A., Ishiwata, R., Jin, MH., Masuda, M., Asou, T., Sugimoto, Y., Aoki, H., Nakamura, T. and Ishikawa, Y. Prostaglandin E 2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling. Circulation, 129, 487-496, 2014.
  7. Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Nakazeki, F., Ide, Y., Koyama, S., Sowa, N., Yahagi, N., Shimano, H., Nakamura, T., Hasegawa, K., Kume, N., Yokode, M., Kita, T., Kimura, T. and Ono, K. MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo. Sci. Rep., 4, 5312, 2014.
  8. Inoue, T., Ohbayashi, T., Fujikawa, Y., Yoshida, H., Akama, T.O., Noda, K., Horiguchi, M., Kameyama, K., Hata, Y., Takahashi, K., Kusumoto, K. and Nakamura, T. Latent TGF-β binding protein-2 is essential for the development of ciliary zonule microfibrils. Hum. Mol. Genet. 23, 5672-5682, 2014.
  9. Sugihara, K., Kobayashi, Y., Suzuki, A., Tamura, T., Motamedchaboki, K., Huang, C.-T., Akama, T.O., Pecotte, J., Frost, P., Bauer, C., Jimenez, J.B.,Nakayama, J., Aoki, D., Fukuda, M.N. Development of pro-apoptotic peptides as potential therapy for peritoneal endometriosis. Nat. Commun. 5, 4478, 2014.
  10. Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Sowa, N., Yahagi, N., Shimano, H., Matsumura, S., Inoue, K., Marusawa, H., Nakamura, T., Hasegawa, K., Kume, N., Yokode, M., Kita, T., Kimura, T. and Ono, K. MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice. Nat. Commun. 4, 2883, 2014.
  11. Sugihara, K., Shibata, T.K., Takata, K., Kimura, T., Kanayama, N., Williams, R., Hatakeyama, S., Akama, T.O., Kuo, C.-W., Khoo, K.-H. and Fukuda, M.N. Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans. FEBS Lett. 587, 3195-3201, 2013.
  12. Noda, K., Dabovic, B., Takagi, K., Inoue, T., Horiguchi, M., Hirai, M., Fujikawa, Y., Akama, TO., Kusumoto, K., Zilberberg, L., Sakai, LY., Koli, K., Naitoh, M., von Melchner, H., Suzuki, S., Rifkin, DB. abd Nakamura, T. Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5. Proc. Natl. Acad. Sci. U.S.A. 110, 2852-2857, 2013.
  13. Suzuki-Anekoji, S., Suzuki, A., Wu, S.W., Angata, K., Murai, K.K., Sugihara, K., Akama, T.O., Khoo, KH., Nakayama, J., Michiko N. and Fukuda, MN. In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. J. Biol. Chem. 288, 5007-5016, 2013
  14. Shibata, T.K., Matsumura, F. Wang, P., Yu, S., Choo, C.C., Khoo, K.H., Kitayama, K., Akama, T.O., Sugihara, K., Kanayama, N., Kojima-Aikawa, K., Seeberger, P.H., Fukuda, M., Suzuki, A., Aoki, D., and Fukuda, M.N. Identification of mono- and di-sulfated N-acetyllactosaminyl oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer. J. Biol. Chem. 287, 6592-6602, 2012.
  15. Horie, T., Baba, O., Kuwabara, Y., Chujo, Y., Watanabe, S., Kinoshita, M., Horiguchi, M., Nakamura, T., Chonabayashi, K., Hishizawa, M., Hasegawa, K., Kume, N., Yokode, M., Kita, T., Kimura, T. and Ono, K. MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice. J. Am. Heart. Assoc. 1, e003376, 2012.
  16. Otani, H., Yoshioka, K., Nishikawa, H., Inagaki, C. and Nakamura, T. Involvement of Protein Kinase C and RhoA in Protease-Activated Receptor 1-Mediated F-Actin Reorganization and Cell Growth in Rat Cardiomyocytes. J. Pharmacol. Sci. 115, 135-143, 2011.
  17. Ohara, H., Akatsuka, S., Nagai, H., Liu, Y., Jiang, L., Okazaki, Y., Yamashita, Y., Nakamura, T. and Toyokuni, S. Stage-specific roles of fibulin-5 during oxidative stress-induced renal carcinogenesis in rats. Free Radic. Res. 45, 211-220, 2011.
  18. Tamura, N., Sugihara, K., Akama, T.O. and Fukuda, M.N. Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelal cells through PKC-delta. Cell Cycle 10, 135-143, 2011.
  19. Parfitt, J.G., Pinali, C., Akama, T.O., Young, R.D., Nishida, K., Quantock, A.J. and Knupp, C. Electron tomography reveals multiple self-association of chondroitin sulfate/dermatan sulfate proteoglycans in Chst5-null mouse corneas. J. Struct. Biol.174, 536-541, 2011.
  20. Hatakeyama, S., Sugihara, K., Shibata, K.T., Nakayama, J., Akama, T.O., Tamura, N., Wong, S-M., Bobkov, A.A., Takano, Y., Ohyama, C., Fukuda, M. and Fukuda, M.N. Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide. Proc., Natl. Acad. Sci. USA.108, 19587-19592, 2011.
  21. Shibata, T.K., Matsumura, F. Wang, P., Yu, S., Choo, C.C., Khoo, K.H., Kitayama, K., Akama, T.O., Sugihara, K., Kanayama, N., Kojima-Aikawa, K., Seeberger, P.H., Fukuda, M., Suzuki, A., Aoki, D. and Fukuda, M.N. Identification of mono- and di-sulfated N-acetyllactosaminyl oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer. J. Biol. Chem. 287, 6592-6602, 2012.

* Conference Articles *

  1. Nakamura, T. Latent TGFβ-binding protein 2 is essential for the stable structure of ciliary zonule microfibrils. Invited talk at ISER2016 (XXII Biennial Meeting of the International Society for Eye Research, Keio Plaza Hotel, Tokyo, Sep. 2016.
  2. Nakamura, T. TGFβ-independent role of LTBPs in microfibril and elastic fiber assembly. Invited talk at Gordon Research Conference on Elastin and Elastic Fiber, Biddeford, USA, July 2013.
  3. Akama,T.O., Fujikawa, Y., Inoue, T. and Nakamura, T. Mutant LTBP-2 proteins lack secretion ability and fibrillin-1 binding activity. The Association for Research in Vision and Ophthalmology (ARVO) annual meeting, Seattle, USA, May, 2013.
  4. Nakamura, T., The essential role of LTBP4 in elastic fiber assembly. Invited talk at Gordon Research Conference on Elastin and Elastic Fiber, Biddeford, U.S.A., July, 2011.
  5. Noda, K., Takagi, K., Horiguchi, M., Inoue, T., Akama, T.O., Melchner, v. H., Hyytiainenn, M., Suzuki, S., Nakamura, T., The essential role for LTBP4 in elastic fiber assembly. Poster presentation at Gordon Research Conference on Elastin and Elastic Fiber, Biddeford, U.S.A., July 24-28, 2011 and selected oral presentation at Gordon Research Seminar on Elastin and Elastic Fiber, Biddeford, U.S.A., July, 2011.
  6. Inoue, T., Ohbayashi, T., Horiguchi, M., Kusumoto, K., Hirai, M., Nakamura, T., The role of LTBP-2 in eye development. Poster at Gordon Research Conference on Elastin and Elastic Fiber, Biddeford, U.S.A., July 24-28, 2011 and selected oral presentation at Gordon Research Seminar on Elastin and Elastic Fiber, Biddeford, U.S.A., July, 2011.
  7. Akama, T. O., Fukuda, M., Fukuda, M.N., Nakamura, T., Distinct roles of β1,3-N-acetylglucosaminyltransferases and carbohydrate 6-O sulfotransferases on corneal keratan sulfate production. 21st International Symposium on Glycoconjugates, Vienna, Austria, Aug. 2011.
  8. Akama, T. O., Fukuda, M., Fukuda, M.N., Nakamura, T., Study of corneal keratan sulfate biosynthesis in vivo using sulfotransferase gene knockout mice. Annual Conference of the Society for Glycobiology, Seattle, U.S.A., Nov. 2011.



Cardiology, Nephrology, and Endocrinology and Metabolism

* Original Articles *

  1. Haiden, M., Miyasaka, Y., Kimura, Y., Tsujimoto, S., Maeba, H., Suwa, Y., Iwasaka, T., Shiojima, I. Effect of eicosapentaenoic acid on regional arterial stiffness: Assessment by tissue Doppler imaging. World J. Cardiol. 4, 256-259, 2012.

* Conference Articles *

  1. Horitani, K., Iwasaki, M., Kishimoto, H., Wada, K., Nakano, M. and Shiojima, I. Repetitive postprandial glucose/triglyceride spikes activates p53 in bone marrow progenitor cells and induce premature aging of bone marrow. 19th International Vascular Biology Meeting, Boston MA, Nov. 2016.
  2. Shiojima, I. Wnt and cardiovascular ageing. European Society of Cardiology, Roma-Italy, Aug.2016.
  3. Horitani, K., Iwasaki, M., Kishimoto, H., Nakano, M. and Shiojima, I. Repetitive postprandial glucose/triglyceride spikes activates p53 in bone marrow progenitor cells and induce premature aging of bone marrow. American Diabetes Association, New Orleans-Louisiana, June, 2016.
  4. Fujita M, Otani H, Shimazu T, Yoshioka K, Sato D, Iwasaki M, Iwasaka T, Tabata Y.Regeneration of the heart by controlled release of antagomir-92a using gelatin hydrogel microspheres-incorporated patch in rats with myocardial infarction. 60th Annual Scientific Session of American College of Cardiology. New Orleans, USA. April, 2011.
  5. Fujita M, Otani H, Shimazu T, Yoshioka K, Iwasaki M, Iwasaka T, Tabata Y.Inhibition of microRNA-92a enhances angiogenesis and cardiomyocyte regeneration through integrin α5-dependent accumulation of cardiac stem cells into the infarcted myocardium. Fujita M, American Heart Association Scientific Sessions 2011. Orlando, USA. April, 2011.



Gastroenterology and Hepatology

* Original Articles *

  1. Kato, K., Ikeura, T., Yanagawa, M., Tomiyama, T., Fukui, T., Uchida, K., Takaoka, M., Nishio, A., Uemura, Y., Satoi, S., Yamada, H. and Okazaki, K. Morphological and immunohistochemical comparison of intrapancreatic nerves between chronic pancreatitis and type 1 autoimmune pancreatitis. Pancreatology 17, 403-410, 2017.
  2. Uchida, K. and Okazaki, K. Roles of Regulatory T and B Cells in IgG4-Related Disease. Curr. Top. Microbiol. Immunol. 401, 93-114, 2017.
  3. Sakao, M., Sakaguchi, Y., Suzuki, R., Takahashi, Y., Kishimoto, M., Fukui, T., Uchida, K., Nishio, A., Matsuzaki, K. and Okazaki, K. Smad2/3 Linker Phosphorylation Is a Possible Marker of Pancreatic Stem/Progenitor Cells in the Regenerative Phase of Acute Pancreatitis. Pancreas 46, 605-613, 2017.
  4. Okazaki, K. and Umehara, H. Current Concept of IgG4-Related Disease. Curr. Top Microbiol. Immunol. 401, 1-17, 2016.
  5. Tanaka, T., Atsumi, N., Nakamura, N., Yana, H., Komai Y., Omachi T., Tanaka, K., Ishigaki, K., Saiga, K., Ohsugi, H., Tokuyama, Y., Imahashi, Y., Hisha, H., Yoshida, N., Kumano, K., Okazaki, K. and Ueno, H. Bmi1-positive cells in the lingual epithelium could serve as cancer stem cells in tongue cancer. Sci. Rep. 6, 39986, 2016.
  6. Ando, Y., Mazzurana, L., Forkel, M., Okazaki, K., Aoi, M., Schmidt, P.T., Mjösberg, J. and Bresso, F. Downregulation of MicroRNA-21 in Colonic CD3+ T Cells in UC Remission. Inflamm. Bowel Dis. 22, 2788-2793, 2016.
  7. Ikeura, T., Miyoshi, H., Shimatani, M., Uchida, K., Takaoka, M. and Okazaki, K. Long-term outcomes of autoimmune pancreatitis. World J. Gastroenterol. 22, 7760-7766, 2016.
  8. Ikeura, T., Horitani, S., Masuda, M., Kasai, T., Yanagawa, M., Miyoshi, H., Uchida, K., Takaoka, M., Miyasaka, C., Uemura, Y. and Okazaki, K. IgG4-related Disease Involving Multiple Organs with Elevated Serum Interleukin-6 Levels. Intern. Med. 55, 2623-2628, 2016.
  9. Suzuki, K., Yokoyama, J., Kawauchi, Y., Honda, Y., Sato, H., Aoyagi, Y., Terai, S., Okazaki, K., Suzuki, Y., Sameshima, Y., Fukushima, T., Sugahara, K., Atreya, R., Neurath, M.F., Watanabe, K., Yoneyama, H. and Asakura H. Phase 1 Clinical Study of siRNA Targeting Carbohydrate Sulphotransferase 15 in Crohn's Disease Patients with Active Mucosal Lesions. J. Crohns. Colitis. 11, 221-228, 2016
  10. Suzuki, K., Arumugam, S., Yokoyama, J., Kawauchi, Y., Honda, Y., Sato, H., Aoyagi, Y., Terai, S., Okazaki, K., Suzuki, Y., Mizumoto, S., Sugahara, K., Atreya, R., Neurath, M.F., Watanabe, K., Hashiguchi, T., Yoneyama, H. and Asakura, H. Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis. PLoS One. 11, e0158967, 2016.
  11. Uchida, K., Miyoshi, H., Ikeura, T., Shimatani, M., Takaoka, M. and Okazaki, K. Clinical and pathophysiological issues associated with type 1 autoimmune pancreatitis. Clin. J. Gastroenterol. 9, 7-12, 2016.
  12. Yoshida, K., Murata, M., Yamaguchi, T., Matsuzaki, K. and Okazaki, K. Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions. J. Clin. Med. 5, 7(1-19), 2016.
  13. Takahashi, Y., Fukui, T., Kishimoto, M., Suzuki, R., Mitsuyama, T., Sumimoto, K., Okazaki, T., Sakao, M., Sakaguchi, Y., Yoshida, K., Uchida, K., Nishio, A., Matsuzaki, K. and Okazaki, K. Phosphorylation of Smad2/3 at the specific linker threonine residue indicates slow-cycling esophageal stem-like cells before re-entry to the cell cycle. Dis. Esophagus. 29, 107-115, 2016.
  14. Fukui, Y., Uchida, K., Sakaguchi, Y., Fukui, T., Nishio, A., Shikata, N., Sakaida, N., Uemura, Y., Satoi, S. and Okazaki, K. Possible involvement of Toll-like receptor 7 in the development of type 1 autoimmune pancreatitis. J. Gastroenterol. 50, 435-444, 2015.
  15. Kurishima, A., Inaba, M., Sakaguchi, Y., Fukui, T., Uchida, K., Nishio, A., Nomura, S. and Okazaki, K. Immunoregulatory function of PIR-A/B+ DCs in the inflammatory responses of dextran sodium sulfate-induced colitis. J. Gastroenterol. 49, 1367-1377, 2014.
  16. Mitsuyama, T., Uchida, K., Sumimoto, K., Fukui, Y., Ikeura, T., Fukui, T., Nishio, A., Shikata, N., Uemura, Y., Satoi, S., Mizuno, N., Notohara, K., Shimosegawa, T., Zamboni, G., Frulloni, L. and Okazaki, K. Comparison of neutrophil infiltration between type 1 and type 2 autoimmune pancreatitis. Pancreatology. 15, 271-280, 2015.
  17. Okazaki, T., Nishio, A., Takeo, M., Sakaguchi, Y., Fukui, T., Uchida, K. and Okazaki, K. Inhibition of the dephosphorylation of eukaryotic initiation factor 2α ameliorates murine experimental colitis. Digestion. 90, 167-178, 2014.
  18. Okazaki, K., Yanagawa, M., Mitsuyama, T. and Uchida, K. Recent advances in the concept and pathogenesis of IgG4-related disease in the hepato-bilio-pancreatic system. Gut Liver. 8, 462-470, 2014.
  19. Kishimoto, M., Fukui, T., Suzuki, R., Takahashi, Y., Sumimoto, K., Okazaki, T., Sakao, M., Sakaguchi, Y., Yoshida, K., Uchida, K., Nishio, A., Matsuzaki, K. and Okazaki, K. Phosphorylation of Smad2/3 at specific linker threonine indicates slow-cycling intestinal stem-like cells before reentry to cell cycle. Dig. Dis. Sci. 60, 362-374, 2015.
  20. Sumimoto, K., Uchida, K., Kusuda, T., Mitsuyama, T., Sakaguchi, Y., Fukui, T., Matsushita, M., Takaoka, M., Nishio, A. and Okazaki, K. The role of CD19+ CD24high CD38high and CD19+ CD24high CD27+ regulatory B cells in patients with type 1 autoimmune pancreatitis. Pancreatology. 14, 193-200, 2014.
  21. Okazaki, K., Uchida, K., Koyabu, M., Miyoshi, H., Ikeura, T. and Takaoka, M. IgG4 cholangiopathy - Current concept, diagnosis, and pathogenesis. J. Hepatol. 61, 690-695, 2014.
  22. Nakayama, S., Nishio, A., Yamashina, M., Okazaki, T., Sakaguchi, Y., Yoshida, K., Fukui, T., Uchida, K. and Okazaki, K. Acquired immunity plays an important role in the development of murine experimental pancreatitis induced by alcohol and lipopolysaccharide. Pancreas. 43, 28-36, 2014.
  23. Kurishima, A., Inaba, M., Sakaguchi, Y., Fukui, T., Uchida, K., Nishio, A., Nomura, S. and Okazaki, K. Immunoregulatory function of PIR-A/B+ DCs in the inflammatory responses of dextran sodium sulfate-induced colitis. J. Gastroenterol. 49, 1367-1377, 2013.
  24. Tomiyama, T., Ueda, Y., Katakai, T., Kondo, N., Okazaki, K. and Kinashi, T. Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase. PLoS One. 8, e73874, 2013.
  25. Koyabu, M., Uchida, K., Sakaguchi, Y., Fukata, N., Kusuda, T., Miyoshi, H., Yoshida, K., Sumimoto, K., Mitsuyama, T., Fukui, T., Nishio, A. and Okazaki, K. Possible Involvement of Foxp3+ Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic:Polycytidylic Acid. Int. J. Rheumatol. 2013, 367325, 2013.
  26. Yamaguchi, T., Matsuzaki, K., Inokuchi, R., Kawamura, R., Yoshida, K., Murata, M., Fujisawa, J., Fukushima, N., Sata, M., Kage, M, Nakashima, O., Tamori, A., Kawada, N., Tsuneyama, K., Dooley, S., Seki, T. and Okazaki, K. Phosphorylated Smad2 and Smad3 signaling: Shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C. Hepatol. Res. 43, 1327-1342, 2013.
  27. Miyoshi, H., Kusuda, T., Kurishima, A., Fukui, Y., Sumimoto, K., Satoi, S., Ohe, C., Uemura, Y., Kwon, AH. and Okazaki, K. Autoimmune pancreatitis with histologically proven lymphoplasmacytic sclerosing pancreatitis with granulocytic epithelial lesions. Intern. Med. 51, 733-737, 2012.
  28. Uchida, K., Kusuda, T., Koyabu, M., Miyoshi, H., Fukata, N., Sumimoto, K., Fukui, Y., Sakaguchi, Y., Ikeura, T., Shimatani, M., Fukui, T., Matsushita, M., Takaoka, M., Nishio, A. and Okazaki, K. Regulatory T cells in type 1 autoimmune pancreatitis. Int. J. Rheumatol. 2012, 795026, 2012.
  29. Okazaki, K. and Umehara, H. Are Classification Criteria for IgG4-RD Now Possible? The Concept of IgG4-Related Disease and Proposal of Comprehensive Diagnostic Criteria in Japan. Int. J. Rheumatol. 2012, 357071, 2012.
  30. Yamashina, M., Nishio, A., Nakayama, S., Okazaki, T., Uchida, K., Fukui, T., Okazaki, K. Comparative study on experimental autoimmune pancreatitis and its extrapancreatic involvement in mice. Pancreas. 41, 1255-1262, 2012.
  31. Umehara, H., Seki, T., Inokuchi, R., Tamai, T., Kawamura, R., Asayama, T., Ikeda, K. and Okazaki, K. Microwave coagulation using a perfusion microwave electrode: Preliminary experimental study using ex vivo and in vivo liver. Exp. Ther. Med. 3, 214-220, 2012.
  32. Fukui, Y., Uchida, K., Sumimoto, K., Kusuda, T., Miyoshi, H., Koyabu, M., Ikeura, T., Sakaguchi, Y., Shimatani, M., Fukui, T., Matsushita, M., Takaoka, M., Nishio, A., Shikata, N., Sakaida, N., Uemura, Y., Satoi, S., Kwon, AH. and Okazaki, K. The similarity of Type 1 autoimmune pancreatitis to pancreatic ductal adenocarcinoma with significant IgG4-positive plasma cell infiltration. J. Gastroenterol. 48, 751-761, 2012.
  33. Matsushita, M., Fukata, N., Omiya, M. and Okazaki, K. Absence of large ulcers indicate that viral therapy is not necessary in cytomegalovirus infection in ulcerative colitis. J. Clin. Gastroenterol. 47, 90-91, 2012.
  34. Watanabe, T., Yamashita, K., Fujikawa, S., Sakurai, T., Kudo, M., Shiokawa, M., Kodama, Y., Uchida, K., Okazaki, K. and Chiba, T. Involvement of activation of toll-like receptors and nucleotide-binding oligomerization domain-like receptors in enhanced IgG4 responses in autoimmune pancreatitis. Arthritis Rheum. 64, 914-924, 2012.
  35. Nishio, A., Asada, M., Uchida, K., Fukui, T., Chiba, T. and Okazaki, K. The Role of Innate Immunity in the Pathogenesis of Experimental Autoimmune Pancreatitis in Mice. Pancreas. 40, 95-102, 2011.
  36. Okazaki, K., Uchida, .K, Miyoshi, H., Ikeura, T., Takaoka, M. and Nishio, A. Recent Concepts of Autoimmune Pancreatitis and IgG4-Related Disease. Clin. Rev. Allergy Immunol. 41, 126-38, 2011.
  37. Fukui, T., Kishimoto, M., Nakajima, A., Yamashina, M., Nakayama, S., Kusuda, T., Sakaguchi, Y., Yoshida, K., Uchida K, Nishio A, Matsuzaki K, Okazaki K.　The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis. J. Gastroenterol. 46, 456-68, 2011.
  38. Okazaki, K., Uchida, K., Koyabu, M., Miyoshi, H., Takaoka, M. Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease. J. Gastroenterol. 46, 277-288, 2011.
  39. Hoshino, S., Kurishima, A., Inaba, M., Ando, Y., Fukui, T., Uchida, K., Nishio, A., Iwai, H., Yokoi, T., Ito, T., Hasegawa-Ishii, S,. Shimada A, Li M, Okazaki K, Ikehara S. Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells. J. Gastroenterol. 46, 1368-1381, 2011.
  40. Kusuda, T., Uchida, K., Miyoshi, H., Koyabu, M., Satoi, S., Takaoka, M., Shikata, N., Uemura, Y., Okazaki, K. Involvement of inducible costimulator- and interleukin 10-positive regulatory T cells in the development of igg4-related autoimmune pancreatitis. Pancreas. 40, 1120-1130, 2011.
  41. Nakase, H., Tamaki, H, Matsuura, M., Chiba, T., Okazaki, K. Involvement of mycobacterium avium subspecies paratuberculosis in TNF-α production from macrophage: possible link between MAP and immune response in Crohn's disease. Inflamm. Bowel Dis. 17, E140-142, 2011.
  42. Ikeura, T., Takaoka, M., Uchida, K., Shimatani, M., Miyoshi, H., Kusuda, T., Kurishima, A., Fukui, Y., Sumimoto, K., Satoi, S., Ohe, C., Uemura, Y., Kwon, AH., Okazaki, K. Autoimmune pancreatitis with histologically proven lymphoplasmacytic sclerosing pancreatitis with granulocytic epithelial lesions. Intern. Med. 51, 733-737, 2012.
  43. Nakajima, A., Fukui, T., Takahashi, Y., Kishimoto, M., Yamashina, M., Nakayama, S., Sakaguchi, Y., Yoshida, K., Uchida, K., Nishio, A., Yodoi, J.and Okazaki, K. Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin. J. Gastroenterol. 47, 978-987, 2012.

* Books *

  1. Okazaki, K. IgG4-related disease, Springer, 128p, 2017.

* Conference Articles *

  1. Ando, Y., Mazzurana, L., Forkel, M., Okazaki, K., Schmidt, P.T., Mjösberg, J. and Bresso, F. MicroRNA-21 is down-regulated in UC remission and is negatively correlated with PDCD4 expression Asian Pacific Digestive Week (APDW) Kobe, Nov. 2016.
  2. Ando, Y., Mazzurana, L., Forkel, M., Okazaki, K., Schmidt, P.T., Mjösberg, J. and Bresso, F. The PDCD4/miR-21 pathway in UC remission Asian Organization for Crohn's and Colitis (AOCC) Kyoto, Japan, July, 2016.
  3. Uchida, K., Fukui, Y., Mitsuyama, T., Miyoshi, H., Ikeura, T., Shimatani, M., Fukui, T., Matsushita, M., Takaoka, M., Nishio, M. and Okazaki, K. The Pathophysiological Role of Toll-like Receptor Signaling in Type 1 Autoimmune Pancreatitis. APDW (Asian Pacific Digestive Week) 2015, Taipei International Convention Center, Taipei, Taiwan, Dec. 2015.
  4. Uchida, K., Mitsuyama, T., Yanagawa, M., Miyoshi, H., Ikeura, T., Shimatani, M., Fukui, T., Takaoka, M., Nishio, A., Mizuno, N., Notohara, K., Zamboni, G., Frulloni, L., Shimosegawa, T. and Okazaki, K. The Difference in Mechanisms of Neutrophil Infiltration between Type 1 and Type2 Autoimmune Pancreatitis. 46th Annual Meeting of American Pancreatic Association, San Diego, Nov. 2015.
  5. Uchida, K., Fukui, Y., Yanagawa, M., Mitsuyama, T., Sumimoto, K., Ikeura, T., Sakaguchi, Y., Shimatani, M., Fukui, T., Matsushita, M., Takaoka, M., Nishio, A., Satoi, S., Kwon, A.H. and Okazaki, K. The Role of Innate Immunity in the Pathogenesis of Type 1 Autoimmune Pancreatitis. 45th Anniversary Meeting of American Pancreatic Association and Japan Pancreatic Society, Hawaii, Nov. 2014.
  6. Sumimoto, K., Uchida, K., Mitsuyama, T., Fukui, Y., Kusuda, T., Miyoshi, H., Fukata, N., Koyabu, M., Sakaguchi, Y., Ikeura, T., Shimatani, M., Fukui, T., Matsushita, M., Takaoka, M., Nishio, A. Okazaki, K. Regulatory B Cells in Type 1 Autoimmune Pancreatitis. DDW2014, Chicago, USA, May, 2014.
  7. Ikeura, T., Takaoka, M., Uchida, K., Shimatani, M., Miyoshi, H., Fukui, Y., Sumimoto, K., Okazaki, K. Which has a higher risk for developing pancreatic cancer, autoimmune pancreatitis or ordinary chronic pancreatitis? The 4th International Forum at the 100th General Meeting of the Japanese Society of Gastroenterology. Tokyo. April, 2014.
  8. Kazushige Uchida, K., Fukui, Y., Mitsuyama, T., Sumimoto, K., Ikeura, T., Sakaguchi, Y., Shimatani, M., Fukui, T., Matsushita, M., Takaoka, M., Nishio, A. and Okazaki, K. Comparison of IgG4-positive Plasma Cell Infiltration Between Type 1 Autoimmune Pancreatitis and Pancreatic Ductal Adenocarcinoma Based On Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. The International Symposium on IgG4-RD and Associated Conditions, Honolulu, USA. Feb. 2014.
  9. Uchida, K., Kusuda, T., Sakaguchi, Y., Yoshida, K., Fukui, T., Nishio, A. and Okazaki, K. Possible role of ICOS and IL-10 Positive Regulatory T Cells in the Development of IgG4-related Autoimmune Pancreatitis. American Pancreatic Association Meeting. Chicago, USA, Nov. 2011.
  10. Okazaki, K., Sumimoto, K., Ikeura, T., Uchida, K. and Takaoka, M. How to recognize the mimickers of pancreas cancer in AIP? Japanese experience. Joint Meeting of the 4th Asian-Oceanic Pancreas Association and 2011 Annual Congress of the Korean Pancreatobiliary Association, Jeju, Korea, Sep. 2011.
  11. Nakayama, S., Nishio, A., Sakaguchi, Y., Yoshida, K., Fukui, T., Uchida, K. and Okazaki, K. The　Participation of innate and Acquired Immunity of Alcoholic Chronic Pancreatitis　DDW2011, Chicago, USA, May, 2011.
  12. Kusuda, T., Uchida, K., Sakaguchi, Y., Yoshida,K., Fukui, T., Nishio, A. and Okazaki, K. Involvement of ICOS and IL-10 Positive Regulatory T Cells in the Development of IgG4-related Autoimmune Pancreatitis. DDW2011, Chicago, USA, May, 2011.
  13. Uchida, K., Kusuda, T., Miyoshi, H., Ikeura, T., Sakaguchi, Y., Yoshida, K., Fukui, T., Shimatani, M., Matsushita, M., Takaoka, M., Nishio, A. and Okazaki, K. Possible role of ICOS positive and IL-10 producing regulatory T cells in patients with autoimmune pancreatitis. Joint Meeting of the International Association of Pancreatology and Indian Pancreas Club Kochi, Kerala, India, Nov. 2011.



Surgery

* Original Articles *

  1. Yamaki, S., Yanagimoto, H., Tsuta, K., Ryota, H. and Kon, M. PD-L1 expression in pancreatic ductal adenocarcinoma is a poor prognostic factor in patients with high CD8+ tumor-infiltrating lymphocytes: highly sensitive detection using phosphor-integrated dot staining. Int. J. Clin. Oncol. in press, 2017.
  2. Kaibori, M., Ishizaki, M., Matsui, K., Nakatake, R., Yoshiuchi, S., Kimura, Y. and Kwon, AH. Perioperative exercise for chronic liver injury patients with hepatocellular carcinoma undergoing hepatectomy. Am. J. Surg. 206, 202-209, 2013.
  3. Kaibori, M., Kubo, S., Nagano, H., Hayashi, M., Haji, S., Nakai, T., Ishizaki, M., Matsui, K., Uenishi, T., Takemura, S., Wada, H., Marubashi, S., Komeda, K., Hirokawa, F., Nakata, Y., Uchiyama, K. and Kwon, AH. Clinicopathological features of recurrence in patients after 10-year disease-free survival following curative hepatic resection of hepatocellular carcinoma. World J. Surg. 37, 820-828, 2013.
  4. Tokuhara, K., Habara, K., Oishi, M., Miki, H., Tanaka, Y., Kaibori, M., Nishizawa, M., Okumura, T. and Kwon, AH. Fluvastatin inhibits the induction of inducible nitric oxide synthase, an inflammatory biomarker, in hepatocytes. Hepatol. Res. 43, 775-784, 2012.
  5. Yamao, J., Toyokawa, H., Kim, S., Yamaki, S., Satoi, S., Yanagimoto, H., Yamamoto, T., Hirooka, S., Matsui, Y. and Kwon, AH. Activation of alpha-smooth muscle actin-positive myofibroblast-like cells after chemotherapy with gemcitabine in a rat orthotopic pancreatic cancer model. J. Hepatobiliary Pancreat. Sci. 20, 206-213, 2012.
  6. Kaibori, M., Tanigawa, N., Kariya, S., Ikeda, H., Nakahashi, Y., Hirohara, J., Koreeda, C., Seki, T., Sawada, S., Okazaki, K. and Kwon, AH. A prospective randomized controlled trial of preoperative whole-liver chemolipiodolization for hepatocellular carcinoma. Dig. Dis. Sci. 57, 1404-1412, 2012.
  7. Araki, Y., Kaibori, M., Matsumura, S., Kwon, AH. and Ito, S. Novel strategy for the control of postoperative pain: long-lasting effect of an implanted analgesic hydrogel in a rat model of postoperative pain. Anesth. Analg. 114, 1338-1345, 2012.
  8. Kaibori, M., Ishizaki, M., Matsui, K. and Kwon, AH. Clinicopathologic characteristics of patients with non-B non-C hepatitis virus hepatocellular carcinoma after hepatectomy. Am. J. Surg. 204, 300-307, 2012.
  9. Inoue, K., Nakane, Y., Michiura, T., Yamada, M., Mukaide, H., Fukui, J., Miki, H., Ueyama, Y., Nakatake, R., Tokuhara, K., Iwamoto, S., Yanagimoto, H., Toyokawa, H., Satoi, S. and Kwon, AH. Ultrasonic scalpel for gastric cancer surgery: a prospective randomized study. J. Gastrointest. Surg. 16, 1840-1846, 2012.
  10. Matsui, Y., Yamaki, S., Yamamoto, T., Isizaki, M., Matsui, K., Yanagimoto, H., Toyokawa, H., Kaibori, M., Satoi, S. and Kwon, AH. Absence of cystic duct leakage using locking clips in 1017 cases of laparoscopic cholecystectomy. Am. Surg. 78, 1228-1231, 2012.
  11. Yokoigawa, N., Ogura, T. and Kwon, AH. Successful surgical control of peritoneal dissemination of hepatocellular carcinoma. Case Rep. Gastroenterol. 6, 612-617, 2012.
  12. Yamada, M., Yao, I., Hayasaka, T., Ushijima, M., Matsuura, M., Takada, H., Shikata, N., Setou, M., Kwon, AH. and Ito, S. Identification of oligosaccharides from histopathological sections by MALDI imaging mass spectrometry. Anal. Bioanal. Chem. 402, 1921-1930, 2012.



Dermatology

* Original Articles *

  1. Thi Hong Nguyen, C., Kambe, N., Kishimoto, I., Ueda-Hayakawa, I. and Okamoto, H. Serum soluble interleukin-2 receptor level is more sensitive than angiotensin-converting enzyme or lysozyme for diagnosis of sarcoidosis and may be a marker of multiple organ involvement. J. Dermatol. in press, 2017.
  2. Ueda-Hayakawa, I., Tanimura, H., Osawa, M., Iwasaka, H., Ohe, S., Yamazaki, F., Mizuno, K. and Okamoto, H. Elevated serum BAFF levels in patients with sarcoidosis: association with disease activity. Rheumatology (Oxford). 52, 1658-1666, 2013.
  3. Ohashi, S., Ueda-Hayakawa, I., Isei, T. and Okamoto, H. Case of diffuse cutaneous systemic sclerosis with anti-Ku and anti-centromere antibodies. J. Dermatol. 40, 558-561, 2013.
  4. Mizuno, K., Suzuki, A., Kato, N., Isei, T. and Okamoto, H. CD8-positive granulomatous mycosis fungoides mimicking generalized granuloma annulare. J. Dermatol. 39, 1068-1069, 2012.

Conference Articles

  1. Nguyen, CTH., Ueda-Hayakawa, I., Yamazaki, F., Mizuno, K., Kambe, N. and Okamoto, H. Properties of CD14+CD16+ cells in psoriatic skin lesions. 25th Congress of the European Academy of Dermatology and Venereology, Vienna, Austria, June, 2016


Plastic and Reconstructive Surgery

* Original Articles *

  1. Ogino, S., Morimoto, N., Sakamoto, M., Jinno, C., Taira, T. and Suzuki, S. Efficacy of gelatin gel sheets sustaining epidermal growth factor for murine skin defects. J. Surg. Res. 201, 446-454, 2016.
  2. Sakamoto, M., Morimoto, N., Ogino, S., Jinno, C., Taira, T. and Suzuki, S. Efficacy of gelatin gel sheets in sustaining the release of basic fibroblast growth factor for murine skin defects. J. Surg. Res. 201, 378-387, 2016.
  3. Sakamoto, M., Morimoto, N., Ogino, S., Jinno, C., Kawaguchi, A., Kawai, K. and Suzuki, S. Preparation of Partial-Thickness Burn Wounds in Rodents Using a New Experimental Burning Device. Ann. Plast. Surg. 76, 652-658, 2016.
  4. Masuoka, H., Morimoto, N., Sakamoto, M., Ogino, S. and Suzuki, S. Exploration of the wound healing effect of topical administration of nicotine in combination with collagen scaffold in a rabbit model. J. Artif. Organs 19, 167-174, 2016.
  5. Morimoto, N., Kakudo, N., Ogura, T., Hara, T., Matsui, M., Yamamoto, M., Tabata, Y. and Kusumoto, K. Easy-to-Use Preservation and Application of Platelet-Rich Plasma in Combination Wound Therapy With a Gelatin Sheet and Freeze-Dried Platelet-Rich Plasma: A Case Report. Eplasty 16, e22, 2016.
  6. Morimoto, N., Jinno, C., Sakamoto, M., Kakudo, N., Yamaoka, T. and Kusumoto, K. An Exploratory Clinical Trial of a Novel Treatment for Giant Congenital Melanocytic Nevi Combining Inactivated Autologous Nevus Tissue by High Hydrostatic Pressure and a Cultured Epidermal Autograft: Study Protocol. JMIR res. protoc. 5, e162, 2016.
  7. Hara, T., Kakudo, N., Morimoto, N., Ogawa, T., Lai, F. and Kusumoto, K. Platelet-rich plasma stimulates human dermal fibroblast proliferation via a Ras-dependent extracellular signal-regulated kinase 1/2 pathway. J. Artif. Organs 19, 372-377, 2016.
  8. Kakudo, N., Morimoto, N., Ogawa, T., Hihara, M., Koseki, R. and Kusumoto, K. Elastofibroma dorsi: a case report with an immunohistochemical and ultrastructural studies. Med. mol. morphol. 49, 42-47, 2016.
  9. Morimoto, N., Kakudo, N., Matsui, M., Ogura, T., Hara, T., Suzuki, K., Yamamoto, M., Tabata, Y. and Kusumoto, K. Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol. BMJ open 5, Article No.e007733, 2015.
  10. Katsube, M., Yoshiura, K. and Kusumoto, K. A Japanese family with popliteal pterygium syndrome. Case Reports Plast. Surg. Hand Surg. 2, 50-52, 2015.
  11. Katsube, M., Kusumoto, K., Nakano, M., Iguchi, Y. and Tanaka, Y. Application of porous hydroxyapatite blocks for maxillofacial deformities. Eur. J. Plast. Surg. 37, 461-468, 2014.
  12. Inoue, T., Ohbayashi, T., Fujikawa, Y., Yoshida, H., Akama, T.O., Noda, K., Horiguchi, M., Kameyama, K., Hata, Y., Takahashi, K., Kusumoto, K. and Nakamura, T. Latent TGFβ binding protein-2 is essential for the development of ciliary zonule microfibrils. Hum. Mol. Genet. 23, 5672-5682, 2014.
  13. Morimoto, N., Kakudo, N., Notodihardjo. P.V., Suzuki, S. and Kusumoto, K. Comparison of neovascularization in dermal substitutes seeded with autologous fibroblasts or impregnated with bFGF applied to diabetic foot ulcers using laser Doppler imaging. Artif. Organs. 17, 352-357, 2014.
  14. Kushida, S., Kakudo, N., Morimoto, N, Hara, T., Ogawa, T., Mitsui, T., Kusumoto, K. Platelet and growth factor concentrations in activated platelet-rich plasma: a comparison of seven commercial separation systems. Artif. Organs. 17, 186-192, 2014.
  15. Kakudo, N., Morimoto, N., Kushida, S., Ogawa, T. and Kusumoto, K. Platelet-rich plasma releasate promotes angiogenesis in vitro and in vivo. Med. Mol. Morphol. 47, 83-89, 2014.
  16. Kakudo, N., Morimoto, N., Ogawa, T. and Kusumoto, K. Potential of adipose-derived stem cells for regeneration medicine: clinical application and usefulness of fat grafting. J. Stem Cell Res. Ther. 4, Article No. 1000204, 2014.
  17. Kushida, S., Kakudo, N., Morimoto, N., Hara, T., Ogawa, T., Mitsui, T. and Kusumoto, K. Platelet and growth factor concentrations in activated platelet-rich plasma: a comparison of seven commercial separation systems. J. Artif. Organs. 17, 186-192, 2014.
  18. Morimoto, N., Kakudo, N., Notodihardjo PV, Suzuki, S. and Kusumoto, K. Comparison of neovascularization in dermal substitutes seeded with autologous fibroblasts or impregnated with bFGF applied to diabetic foot ulcers using laser Doppler imaging. J. Artif. Organs. 17, 352-357, 2014.
  19. Inoue, T., Ohbayashi, T., Fujikawa, Y., Yoshida, H., Akama, TO., Noda, K., Horiguchi, M., Kameyama, K., Hata, Y., Takahashi, K., Kusumoto, K. and Nakamura, T. Latent TGFβ binding protein-2 is essential for the development of ciliary zonule microfibrils. Hum. Mol. Genet. 23, 5672-5682, 2014.
  20. Katsube, M.,Kusumoto, K., Nakano, M., Iguchi, Y. and Tanaka, Y. Application of porous hydroxyapatite blocks for maxillofacial deformities. Eur. J. Plast. Surg. 37, 461-468, 2014.
  21. Kakudo, N., Tanaka, Y., Morimoto, N., Ogawa, T., Kushida, S., Hara, T. and Kusumoto, K. Adipose-derived regenerative cell (ADRC)-enriched fat grafting: optimal cell concentration and effects on grafted fat characteristics. J. Transl. Med. 11, Article No.254, 2013.
  22. Kakudo, N., Kushida, S., Suzuki, K. and Kusumoto, K. Effects of glycolic acid chemical peeling on facial pigment deposition: Evaluation using novel computer analysis of Digital-camera-captured images. J. Cos. Derm. 12, 281-286, 2013.
  23. Kushida, S., Kakudo, N., Suzuki, K. and Kusumoto, K. Effects of platelet-rich plasma on proliferation and myofibroblastic differentiation in human dermal fibroblasts. Ann. Plast. Surg. 71, 219-224, 2013.
  24. Kakudo, N., Kushida, S., Suzuki, K., Ogura, T., Notodihardjo, P.V., Hara, T. and Kusumoto, K. Effects of transforming growth factor-beta1 on cell motility, collagen gel contraction, myofibroblastic differentiation, and extracellular matrix expression of human adipose-derived stem cell. Hum. Cell, 25, 87-95, 2012.
  25. Notodiharjo, FZ., Kakudo, N., Kushida, S., Suzuki, K. and Kusumoto, K. Bone regeneration with BMP-2 and hydroxyapatite in critical-size calvarial defects in rats. J. Craniomaxillofac. Surg. 40, 287-291, 2012.
  26. Kakudo, N., Kushida, S., Minakata, T., Suzuki, K. and Kusumoto, K. Platelet-rich plasma promotes epithelialization and angiogenesis in a splitthickness skin graft donor site. Med. Mol. Morphol. 44, 233-236, 2011.
  27. Kakudo, N., Kushida, S., Suzuki, K., Matsumoto, N. and Kusumoto K. The effect of C3 transferase on human adipose-derived stem cells. Hum. Cell 24, 165-169, 2011.

* Books *

  1. Kakudo, N., Morimoto, N., Kushida, S., Iguchi, Y. and Kusumoto, K. Quantitative Evaluation of Facial Pigentation, Wrinkles, and Pores Using Robo Skin Analyzer. Advances in Image Analysis Research vol.11, Nova Science Publishers, 239-244, 2014
  2. Kakudo, N., Kushida, S., Saito, N., Suzuki, K. and Kusumoto, K. A Procedure for the Assessment of Skin Aging. Skin Aging: New Research, Nova Science Publishers, 131-136, 2013.

* Conference Articles *

  1. Morimoto, N., Kakudo, N., Koseki, R., Ogura, T., Hara, T. and Kusumoto, K. Easy-to-use preservation and application of platelet-rich plasma; The combination wound therapy with a gelatin sheet and freeze-dried platelet-rich plasma. 5th congress of WUWHS2016, Florence, Italy, Sep. 2016.
  2. Kusumoto, K., Fukuda, S., Miyake, Y., Morimoto, N., Kakudo, N., Ogura, T., Hara, T. and Koseki, R. Platelet-Rich Plasma and the ulcer treatment with various applications. 5th congress of WUWHS2016, Florence, Italy, Sep. 2016.
  3. Morimoto, N., Kakudo, N., Koseki, R., Ogura, T., Hara, T. and Kusumoto, K. Easy-to-use preservation and application of platelet-rich plasma; The combination wound therapy with a gelatin sheet and freeze-dried platelet-rich plasma. 5th congress of WUWHS2016, Florence, Italy, Sep. 2016.
  4. Kusumoto, K. Platelet-rich plasma and the combination usage at the adipoinjection. The 3rd Chinese Academic Conference on Adipose Plastic Surgery & Symposium on Adipose Transplantation, Shanghai(China), July, 2016.
  5. Sakamoto, M., Morimoto, N., Ogino, S., Jinno, C., Ito, R. and Suzuki, S. Development of Gelatin Gel Sheets Sustaining EGF and bFGF. The 13th Japan-Korea Congress of Plastic and Reconstructive Surgery, Kanazawa, May, 2016.
  6. Kusumoto, K., Morimoto, N., Fukuda, S., Kakudo, N., Miyake, Y., Valentin, P., Ogura, T. and Hara, T. Principles of PRP and the PRP therapy. The 12th Korea-Japan Congress of Plastic and Reconstructive Surgery, Incheon, Korea, May 2014.
  7. Kusumoto, K., Suzuki, K., Fukuda, S., Miyake, Y., Kakudo, N., Tanaka, Y., Sasao, T., Kushida, S., Katsube, M., Valentin, P., Ogura, T. Autologous Platelet-rich Plasma(PRP) and the Applications for wrinkle care and ulcer treatment. The 21st Japan-China Joint Congress on Plastic Surgery, Fukuoka, Nov. 2011.
  8. Kushida, S., Kakudo, N., Suzuki, K., Kusumoto, K. Platelet-rich Plasma Induces Myofibroblastic Differentiation in Human Dermal Fibroblasts IPRAS 2011. Vancouver, Canada, May 2011.



Ophthalmology

* Original Articles *

  1. Kimura, M., Ogata, N., Shima, C. and Takahashi, K. Choroidal melanoma with massive extraocular extensions through sclera. Clin. Ophthalmol. 6, 2081-2084, 2012.
  2. Yoshikawa, T., Nishimura, T., Minamino, K., Takahashi, K. A long-term follow-up of peripapillary retinoschisis with optic disc hypoplasia. Int. Ophthalmol. 33, 425-428, 2012.
  3. Matsuoka, M., Ogata, N., Matsuyama, K., Yoshikawa, T., Takahashi, K. Intraocular pressure in Japanese diabetic patients. Clin. Ophthalmol. 6, 1005-1009, 2012.
  4. Tateno, H., Taomoto, M., Jo, N., Takahashi, K. and Uemura, Y. Clinical and histopathological features of a suspected case of fish-eye disease. Jpn. J. Ophthalmol. 56, 453-457, 2012.
  5. Shima, C., Adachi, Y., Minamino, K., Okigaki, M., Shi, M., Imai, Y., Yanai, S., Takahashi, K. and Ikehara, S. Neuroprotective effects of granulocyte colony-stimulating factor on ischemia-reperfusion injury of the retina. Ophthalmic Res.. 48, 199-207, 2012 .

* Conference Articles *

  1. Mori, H. Changes in immunostaining of five elastic fiber components in Bruch’s membrane and laser-induced choroidal neovascularization in mice ARVO2017, Seattle, U.S.A. May, 2016.
  2. Mori, H. Development and age-related changes of the elastic lamina of Bruch’s membrane in mice eyes ARVO-Asia 2017, Brisbane, Australia, Feb. 2016.



Radiology

* Original Articles *

  1. Kanno, S., Utsunomiya, K., Kono, Y., Tanigawa, N. and Sawada, S. The effect of radiation exposure on multidrug resistance: in vitro and in vivo studies using non-small lung cancer cells. EJNMMI Res. 5, 11, 2015.
  2. Kono, Y., Utsunomiya, K., Kanno, S. and Tanigawa, N. Longitudinal time dependent effects of irradiation on multidrug resistance in a non-small lung cancer cell line. Mol. Cancer Ther. 13, 2706-2712, 2014.
  3. Nakatani, M., Tanigawa, N., Kariya, S., Komemushi, A., Yagi, R. and Sawada, S. Analysis of factors influencing accuracy and complications in CT-guided lung biopsy. Minim. Invasive. Ther. Allied Technol. 21, 415-422, 2012.
  4. Kariya, S., Komemushi, A., Nakatani, M., Yoshida, R., Sawada, S. and Tanigawa, N. CO2 microbubble contrast enhancement in x-ray angiography. Clin. Radiol. 68, 346-351, 2012.



Clinical Sciences and Laboratory Medicine
Pathology and Laboratory Medicine

* Original Articles *

  1. Takahashi, H. Upregulation of the renin-angiotensin-aldosterone-ouabain system in the brain is the core mechanism in the genesis of all types of hypertension. Int. J. Hypertens. 242728, 2012.
  2. Takahashi, H., Yoshika, M., Komiyama, Y., Nishimura, M. The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain. Hypertension Res. 34, 1147-1160, 2011.
  3. Yoshika, M., Komiyama, Y., Takahashi, H. An ouabain-like factor is secreted from immortalized hypothalamic cells in an aldosterone-dependent manner. Neurochem. int. 59, 104-108, 2011.
  4. Yoshika, M., Komiyama, Y., Takahashi, H. Isolation of marinobufotoxin from the supernatant of cultured PC12 cells. Clin. exp. pharmacol. physiol. 38, 334-337, 2011.



Biophysics

* Original Articles *

  1. Kageshima, M., Maruyama, T., Akama, T. and Nakamura, T. Novel magnetic indenter for rheological analysis of thin biological sheet for regenerative medicine. Rev. Sci. Instrum. 87, 074302 (1-12), 2016.
  2. Niiyama, Y., Tuji, A., Takemoto, K. and Ichise, S. Pseudanabaena sp. nov. and P. subfoetida sp. nov. (Cyanophyta/ Cyanobacteria) producing 2-methylisoborneol from Japan. Fottea 16, 1-11, 2016.
  3. Ikegaya, H., Suzuki, S., Ichise, S., Furuta, S., Wakabayashi, S., Ohigashi, T., Bamba, D., Namba, H., Kihara, H., Kishimoto, N., Takemoto, K. Estimation of organic carbon content of the cyanobacterium synechococcus sp. by soft X-ray microscopy. Geomicrobiol. J. 32, 827-835, 2015.
  4. Takemoto, K., Yoshimura, M., Yamamoto, A., Ichise, S., Namba, H. and Kihara, H. Imaging of musty-odor producing filamentous cyanobacteria by various microscopies. AIP Conf. Proc. 1696, 020024, 2014.
  5. Kageshima, M. Layer-resolved relaxation dynamics of confined water analyzed through subnanometer shear measurement. Eur. phys. Lett. 107, 66001, 2014.
  6. Matsumura, Y., Shinjo, M., Matsui, T., Ichimura, K., Song, J. and Kihara H. Structural study of hNck2 SH3 domain protein in solution by circular dichroism and X-ray solution scattering. Biophys. Chem. 175-176, 39-46. 2013.
  7. Takemoto, K., Usui, K., Ohigashi, T., Fujii, H., Yoshimura, M., Namba, H. and Kihara, H. Improvement of cryogenic 3-dimensional observation system of soft x-ray microscope at the SR center of Ritsumeikan University. J. Physics Conf. Ser. 463, 012009, 2013.
  8. Takemoto, K., Mizuta, G., Yamamoto, A., Yoshimura, M., Ichise, S., Namba, H. and Kihara, H. Soft x-ray imaging of intracellular granules of filamentous cyanobacterium generating musty smell in Lake Biwa. Journal of Physics: Conference Series 2013 463, 012052, 2013.
  9. Takemoto, K., Ikegaya, H., Yaji, T., Ichise, S., Ohta, T. and Kihara, H. Infrared micro-spectroscopy observation of plantplankton with in lake Biwa. Memoirs of the SR Center, Ritsumeikan University 14, 173-17. 2012.
  10. Takemoto, K., Kimura, M., Usui, K., Ohigashi, T., Fujii, H., Nakanishi, K., Namba, H., Kihara, H. Observations of biological specimens at cryo-temperatures with soft X-ray microscope at the SR center of Ritsumeikan University. AIP Conf. Proc. 1365, 419-422, 2011.
  11. Takemoto, K., Narumi, I., Satoh, K., Ohigashi, T., Namba, H. and H. Kihara, New approach for x-ray micro-imaging of live cells in carbon window region at subzero temperatures with the use of antifreeze. AIP Conf. Proc. 1365, 415-418, 2011.
  12. Takemoto, K., Ichise, S., Ohigashi, T., Namba, H. and Kihara, H. X-ray Imaging of Mucilaginous Sheath of Phytoplankton in Lake Biwa by Soft X-ray Microscope. AIP Conf. Proc. 1365, 373-376, 2011.
  13. Ohigashi, T., Fujii, H., Usui, K., Namba, H. Mizutani, K. Takemoto, and Kihara, H. Development of Computer Tomography System for the Soft X-ray Microscope at Ritsumeikan University. AIP Conf. Proc. 1365, 124-127, 2011.
  14. Matsumura, Y., Shinjo, M., Okishio, N. and Kihara, H. Time-resolved kinetic refolding of PI3K SH3 in the presence of 45% ethylene glycol at pH 6. Photon Factory Activity Report, 28, 247.
  15. Qin, Z., Matsumura, Y., Shinjo, M., Kihara, H. Structural analysis of α-helix rich intermediate of bovine β-lactoglobulin on its folding pathway. Photon Factory Activity Report, 28, 246, 2011.
  16. Matsumura, Y., Shinjo, M., Mahajan, A., Tsai, M-D. and Kihara, H. Time-resolved SAXS on Ki67 FHA domain refolding at cryo conditions. Photon Factory Activity Report, 28, 245, 2011.
  17. Matsumura, Y., Shinjo, M., Okishio, N. and Kihara, H. Unfolding of PI3K SH3 in the presence of 45% ethylene glycol at pH 6. Photon Factroy Activity Report, 28, 248, 2011.
  18. Matsumura, Y., Shinjo, M., Mahajan, A., Tsai, M-D. and Kihara, H. Time-resolved SAXS on FHA1 domain of Rad53 refolding at cryo conditions. Photon Factroy Activity Report, 28, 244, 2011.
  19. Shinjo, M., Morimoto, Y., Kojima, M., Li, J., Jin, X., Matsumura, Y., Kihara, H. Structural analysis of srcSH3 intermediate on its folding pathway. Photon Factory Activity Report, 28, 242, 2011.
  20. Usui, K., Ohigashi, T., Namba, H., Takemoto, K., Kihara, H. Development of the New Sample Cooling System for the Full-filed Imaging Soft X-ray Microscope Memoirs of the SR Center, Memoirs of the SR Center, Ritsumeikan University, 13, 207-209, 2011.
  21. Takemoto, K., Ichise, S., Ohigashi, T., Namba, H., Kihara, H. Soft x-ray imaging of Leptolyngbya tenis (Phormidium tenue) in Lake Biwa Memoirs of the SR Center, Memoirs of the SR Center, Ritsumeikan University, 13, 205-206, 2011.
  22. Ohigashi, T., Namba, H., Takemoto, K., Kihara, H. Improvement of Illumination Optics of the Full-field Imaging Soft X-ray Microscope, Memoirs of the SR Center, Ritsumeikan University, 13, 201-204, 2011.
  23. Fujii, H., Ohigashi, T., Namba, H., Takemoto, K., Kihara, H. Study of quantitative analytical method for soft X-ray nanotomography at BL-12 Memoirs of the SR Center, Memoirs of the SR Center, Ritsumeikan University, 13, 197-200, 2011.

* Conference Articles *

  1. Kageshima, M., Maruyama, T., Akama, T. and Nakamura, T. Rheological Study of Cell Sheet and Matrix Sheet with Home-Built Magnetic Indenter. International Conference on Rheology (ICR2016), Kyoto, Aug. 2016.
  2. Takemoto, K., Yoshimura, M., Ohigashi, T., Namba, H. and Kihara, H. Application of soft X-ray microscopy to environmental microbiology of hydrosphere. The 13th International Conference on X-ray microscopy (XRM2016), Oxford, UK, Aug. 2016.
  3. Shinjo, M., Morimoto, Y., Kojima, M., Li, J., Jin, X., Matsumura, Y., Kihara, H. Structural analysis of α-helix-rich intermediate of src SH3 on its folding pathway. 12nd PSSJ annual meeting , Osaka, June, 2011.
  4. Matsumura, Y., Okishio, N. and Kihara, H. Multiple folding intermediates of three SH3 domains (src, Fyn and PI3K). 12nd PSSJ annual meeting , Osaka, June, 2011.
  5. Matsumura, Y., Shinjo, M., Li, J., Jin, X., Ichimura, K. and Kihara, H. Time-Resolved Study on Folding Landscapes of SH3 Domain Proteins. PF symposium, Tsukuba, July, 2011.
  6. Matsumura, Y., Jin, X., Li, J., Shinjo, M. and Kihara, H. Radiation protection effect of ethylene glycol and glycerol on proteins. PF symposium, Tsukuba, July, 2011.
  7. Shinjo, M., Morimoto, Y., Kojima, M., Li, J., Jin, X., Matsumura, Y., Kihara, H. Structural Analysis of α-Helix-Rich Intermediate of src SH3 on its Folding Pathway by SAXS_MD, The 5th International Symposium "Molecular Science of Fluctuations toward Biological Functions", Nara, Japan, January, 2012.
  8. Matsumura, Y., Ichimura, K., Song, J., Kihara, H. Folding of hNck2 SH3 Domain, The 5th International Symposium "Molecular Science of Fluctuations toward Biological Functions", Nara, Japan, January, 2012.


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